Rasmussen B B, Pedersen B V, Thorpe S M, Hilkens J, Hilgers J, Rose C
Cancer Res. 1985 Mar;45(3):1424-7.
Three monoclonal antibodies, raised against human milk fat globule membranes, have been applied to 194 primary human breast carcinomas. The detected antigenic sites were found to be heterogeneously distributed. A statistical association with estrogen receptor content and grade of anaplasia was found for two of the antigens, Mam 3a and Mam 3b. The presence of all three antigens was independent of menopausal status, age, primary lymph node metastases, and progesterone receptor status. Life table analysis showed a better survival for patients with tumors positive for Mam 3b. The effect of these variables on recurrence-free survival has been analyzed using a Cox regression model. It is found that the most important prognostic factors are the number of positive lymph nodes, the estrogen receptor content, and the menopausal status of the high-risk patients. The ability of a model based on these factors to predict recurrence is not significantly improved by including any of the three surface antigens.
三种针对人乳脂肪球膜产生的单克隆抗体已应用于194例原发性人类乳腺癌。检测到的抗原位点呈异质性分布。发现其中两种抗原Mam 3a和Mam 3b与雌激素受体含量和间变程度存在统计学关联。所有三种抗原的存在均与绝经状态、年龄、原发性淋巴结转移和孕激素受体状态无关。生存表分析显示，Mam 3b阳性肿瘤患者的生存期更长。已使用Cox回归模型分析了这些变量对无复发生存的影响。发现最重要的预后因素是高危患者的阳性淋巴结数量、雌激素受体含量和绝经状态。通过纳入三种表面抗原中的任何一种，基于这些因素的模型预测复发的能力并未得到显著改善。
