Walker R A
Department of Pathology, University of Leicester, Leicester Royal Infirmary, UK.
Br J Cancer. 1990 Sep;62(3):462-6. doi: 10.1038/bjc.1990.319.
The milk fat globule membrane antibodies HMFG1, HMFG2, NCRC 11 and four of the Mam 6 series, and the lectins peanut agglutinin, wheat germ agglutinin, Concanavalin A, Lotus tetragonolobus and Ulex europaeus I have been applied to 115 stage I and II breast carcinomas (median follow up = 36 months) to assess their value as prognostic markers. Of the milk fat globule membrane antibodies only NCRC 11 staining showed a relationship to development of recurrent disease and overall survival, but this did not act as an independent indicator over and above that provided by histological grade. None of the lectins gave prognostic information, including those whose binding related to node status or grade. It is concluded that for short-term prognosis none of the markers can given independent prognostic information over and above that provided by histological evaluation.
已将乳脂肪球膜抗体HMFG1、HMFG2、NCRC 11以及Mam 6系列中的四种，还有凝集素花生凝集素、麦胚凝集素、刀豆球蛋白A、四角豆凝集素和荆豆凝集素应用于115例I期和II期乳腺癌（中位随访时间 = 36个月），以评估它们作为预后标志物的价值。在乳脂肪球膜抗体中，只有NCRC 11染色显示与疾病复发和总生存期的发展有关，但这并非是独立于组织学分级之外的指标。没有一种凝集素能提供预后信息，包括那些其结合与淋巴结状态或分级相关的凝集素。结论是，对于短期预后，没有一种标志物能提供独立于组织学评估之外的预后信息。
