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Targeting undruggable protein KRAS for cancer therapy: novel opportunities and challenges.

作者信息

Yang Xin, Li Xiang, Zhang Yue-Lin, Zhang Sheng-Nan, Zhang Miao, Sun Chong, Yang Li, Liu Hong-Min, Yuan Shuo

机构信息

Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Department of Obstetrics and Gynecology, Zhengzhou Key Laboratory of Endometrial Disease Prevention and Treatment Zhengzhou China, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

Future Med Chem. 2025 Jan;17(2):143-147. doi: 10.1080/17568919.2024.2444865. Epub 2024 Dec 23.

Abstract
摘要

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本文引用的文献

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Targeting cancer with small-molecule pan-KRAS degraders.用小分子泛 KRAS 降解剂靶向癌症。
Science. 2024 Sep 20;385(6715):1338-1347. doi: 10.1126/science.adm8684. Epub 2024 Sep 19.
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Targeting KRAS in cancer.针对癌症中的 KRAS 靶点。
Nat Med. 2024 Apr;30(4):969-983. doi: 10.1038/s41591-024-02903-0. Epub 2024 Apr 18.

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