原钙黏蛋白-19在脑功能中的复杂作用：聚焦于催产素系统 - Suppr

Suppr

超能文献

The complex role of protocadherin-19 in brain function: a focus on the oxytocin system.

作者信息

Mazzoleni Sara, Busnelli Marta, Bassani Silvia

机构信息

CNR Institute of Neuroscience, Vedano al Lambro, Italy (Mazzoleni S, Busnelli M, Bassani S).

NeuroMi Milan Center for Neuroscience, Milan, Italy (Busnelli M, Bassani S).

出版信息

Neural Regen Res. 2025 Nov 1;20(11):3211-3212. doi: 10.4103/NRR.NRR-D-24-00847. Epub 2024 Oct 22.

DOI:10.4103/NRR.NRR-D-24-00847

PMID:39715087

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11881728/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43d3/11881728/f3b6d6ebed96/NRR-20-3211-g001.jpg

相似文献

The complex role of protocadherin-19 in brain function: a focus on the oxytocin system.原钙黏蛋白-19在脑功能中的复杂作用：聚焦于催产素系统

Neural Regen Res. 2025 Nov 1;20(11):3211-3212. doi: 10.4103/NRR.NRR-D-24-00847. Epub 2024 Oct 22.

Comparative analysis of protocadherin-11 X-linked expression among postnatal rodents, non-human primates, and songbirds suggests its possible involvement in brain evolution.比较分析表明，protocadherin-11 X 连锁表达在产后啮齿动物、非人类灵长类动物和鸣禽中存在，提示其可能参与了大脑进化。

PLoS One. 2013;8(3):e58840. doi: 10.1371/journal.pone.0058840. Epub 2013 Mar 18.

A rat model of a focal mosaic expression of PCDH19 replicates human brain developmental abnormalities and behaviours.PCDH19局灶性镶嵌表达的大鼠模型可复制人类脑发育异常及行为表现。

Brain Commun. 2022 Apr 5;4(3):fcac091. doi: 10.1093/braincomms/fcac091. eCollection 2022.

Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain.原钙黏蛋白2C：原钙黏蛋白2亚家族的一个新成员，在发育中的大脑中与OL-原钙黏蛋白以冗余方式表达。

Biochem Biophys Res Commun. 1999 Jul 14;260(3):641-5. doi: 10.1006/bbrc.1999.0950.

Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.原钙黏蛋白-19、原钙黏蛋白-17和钙黏蛋白-6在成年斑马鱼大脑中的差异表达。

J Comp Neurol. 2015 Jun 15;523(9):1419-42. doi: 10.1002/cne.23746. Epub 2015 Apr 7.

Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.原钙黏蛋白 15 在听觉和平衡感知中的力学和功能的结构决定因素。

Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):24837-24848. doi: 10.1073/pnas.1920444117. Epub 2020 Sep 22.

Expression of protocadherin-9 and protocadherin-17 in the nervous system of the embryonic zebrafish.原钙黏蛋白-9和原钙黏蛋白-17在斑马鱼胚胎神经系统中的表达。

Gene Expr Patterns. 2009 Oct;9(7):490-6. doi: 10.1016/j.gep.2009.07.006. Epub 2009 Jul 16.

Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster.多个分散在基因簇中的神经元抑制性元件对原钙黏蛋白基因表达的调控。

Nucleic Acids Res. 2010 Aug;38(15):4985-97. doi: 10.1093/nar/gkq246. Epub 2010 Apr 12.

Protocadherin-17 function in Zebrafish retinal development.原钙黏蛋白 17 在斑马鱼视网膜发育中的功能。

Dev Neurobiol. 2013 Apr;73(4):259-73. doi: 10.1002/dneu.22053. Epub 2013 Jan 24.

Identification and comparative analysis of the protocadherin cluster in a reptile, the green anole lizard.鉴定并比较分析一种爬行动物，绿鬣蜥中的原钙黏蛋白基因簇。

PLoS One. 2009 Oct 29;4(10):e7614. doi: 10.1371/journal.pone.0007614.

引用本文的文献

Molecular basis of autism spectrum disorders.自闭症谱系障碍的分子基础

Mol Biol Rep. 2025 May 28;52(1):508. doi: 10.1007/s11033-025-10604-1.

本文引用的文献

Oxytocin receptors in the Magel2 mouse model of autism: Specific region, age, sex and oxytocin treatment effects.自闭症Magel2小鼠模型中的催产素受体：特定区域、年龄、性别及催产素治疗效果

Front Neurosci. 2023 Mar 14;17:1026939. doi: 10.3389/fnins.2023.1026939. eCollection 2023.

Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression.条件性 PCDH19 杂合表达敲除小鼠模型中神经元网络活动和连接受损。

Mol Psychiatry. 2024 Jun;29(6):1710-1725. doi: 10.1038/s41380-023-02022-1. Epub 2023 Mar 30.

in Males: Are Hemizygous Variants Linked to Autism?在男性中：半合子变异与自闭症有关吗？

Genes (Basel). 2023 Feb 27;14(3):598. doi: 10.3390/genes14030598.

The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.癫痫相关蛋白 PCDH19 经 NMDA 受体依赖性蛋白水解切割，调节即刻早期基因的表达。

Cell Rep. 2022 May 24;39(8):110857. doi: 10.1016/j.celrep.2022.110857.

A standardized patient-centered characterization of the phenotypic spectrum of PCDH19 girls clustering epilepsy.PCDH19 女孩聚类性癫痫表型谱的以患者为中心的标准化特征描述。

Transl Psychiatry. 2020 May 4;10(1):127. doi: 10.1038/s41398-020-0803-0.

The Role of Protocadherin 19 (PCDH19) in Neurodevelopment and in the Pathophysiology of Early Infantile Epileptic Encephalopathy-9 (EIEE9).原钙黏蛋白 19（PCDH19）在神经发育和早发性婴儿癫痫脑病-9（EIEE9）发病机制中的作用。

Dev Neurobiol. 2019 Jan;79(1):75-84. doi: 10.1002/dneu.22654. Epub 2019 Jan 18.

Protocadherin 19 (PCDH19) interacts with paraspeckle protein NONO to co-regulate gene expression with estrogen receptor alpha (ERα).原钙黏蛋白19（PCDH19）与旁斑蛋白NONO相互作用，与雌激素受体α（ERα）共同调节基因表达。

Hum Mol Genet. 2017 Jun 1;26(11):2042-2052. doi: 10.1093/hmg/ddx094.

Lifespan oxytocin signaling: Maturation, flexibility, and stability in newborn, adolescent, and aged brain.寿命期内的催产素信号传导：新生儿、青少年和老年大脑中的成熟、灵活性与稳定性

Dev Neurobiol. 2017 Feb;77(2):158-168. doi: 10.1002/dneu.22450.

Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency.女性癫痫中原钙黏蛋白19（PCDH19-FE）的突变导致别孕烯醇酮缺乏。

Hum Mol Genet. 2015 Sep 15;24(18):5250-9. doi: 10.1093/hmg/ddv245. Epub 2015 Jun 29.

Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism.神经行为学模型自闭症：神经肽催产素受体缺失小鼠认知灵活性损伤、社会交往缺陷、攻击行为增加和易发性癫痫的药物干预

Biol Psychiatry. 2011 May 1;69(9):875-82. doi: 10.1016/j.biopsych.2010.12.022. Epub 2011 Feb 21.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验