Dibner-Dunlap M E, Eckberg D L, Magid N M, Cintrón-Treviño N M
Circulation. 1985 Apr;71(4):797-804. doi: 10.1161/01.cir.71.4.797.
We tested the hypothesis that transdermal scopolamine increases vagal-cardiac nervous outflow over the long term in 16 healthy young men. Twenty-four hours after application of one scopolamine patch, the average RR interval was increased by 13% and the average standard deviation of the RR interval (taken as an index of the level of vagal-cardiac nervous activity) was increased by 31%. Baroreceptor-cardiac reflex responsiveness (as reflected by prolongation of RR interval provoked by graded neck suction) also was increased substantially. These findings suggest that vagal-cardiac nervous activity can be augmented pharmacologically in man on a long-term basis. Since vagal outflow influences cardiac electrical properties in an important way, these findings may have therapeutic implications.
我们在16名健康年轻男性中测试了以下假设：长期使用透皮东莨菪碱会增加迷走神经对心脏的神经输出。在使用一片东莨菪碱贴片24小时后，平均RR间期增加了13%，RR间期的平均标准差（作为迷走神经对心脏神经活动水平的指标）增加了31%。压力感受器-心脏反射反应性（通过分级颈部负压吸引引起的RR间期延长反映）也显著增加。这些发现表明，在人类中，迷走神经对心脏的神经活动可以通过药物长期增强。由于迷走神经输出以重要方式影响心脏电特性，这些发现可能具有治疗意义。
