Roux Hugo Fernando Georges, Touret Franck, Rathelot Pascal, Sciò Pietro, Coluccia Antonio, Vanelle Patrice, Roche Manon
Aix-Marseille Université, CNRS, ICR UMR_7273, LPCR, Faculté de Pharmacie, Marseille 13385, France.
Unité des Virus Émergents (UVE: Aix-Marseille Université, Università di Corsica, IRD 190, Inserm 1207, IRBA), Marseille 13284, France.
ACS Infect Dis. 2025 Jan 10;11(1):21-46. doi: 10.1021/acsinfecdis.4c00606. Epub 2024 Dec 23.
Enterovirus (EV) is a genus that includes a large diversity of viruses spread around the world. They are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease (HFMD). A vaccine is marketed in China for the prevention of HFMD caused by EV-A71. Despite the need, no antiviral is marketed to date. Therefore, several compounds have been currently evaluated to inhibit non-polio Enterovirus (NPEV), namely direct antiviral agents and host target inhibitor. We propose to make a review of the latest molecules evaluated as NPEV inhibitors and to summarize structure-activity relationships between these inhibitors and their target. We provide access to all recent information on Enterovirus inhibitors, regardless of the species, to facilitate the design of future broad-spectrum drugs.
肠道病毒（EV）是一个包含多种在全球传播的病毒的属。它们是众多具有季节性聚集性疾病的主要病因，如手足口病（HFMD）。中国有一种用于预防由EV - A71引起的手足口病的疫苗上市。尽管有需求，但迄今为止尚无抗病毒药物上市。因此，目前已经对几种化合物进行了评估，以抑制非脊髓灰质炎肠道病毒（NPEV），即直接抗病毒剂和宿主靶点抑制剂。我们建议对被评估为NPEV抑制剂的最新分子进行综述，并总结这些抑制剂与其靶点之间的构效关系。我们提供了关于肠道病毒抑制剂的所有最新信息，无论其种类如何，以促进未来广谱药物的设计。
