Design, Synthesis and Application of 1,4-disubstituted 1,2,3-triazole Based Chemosensors: A Promising Avenue.

The 1,2,3-triazole-based chemosensors, synthesized through Cu(I)-catalyzed azide-alkyne cycloaddition via 'click chemistry', offer a straightforward yet highly effective method for detecting metal cations and anions with remarkable accuracy, selectivity and sensitivity, making them invaluable across various fields such as chemistry, pharmacology, environmental science and biology. The selective recognition of these ions is crucial due to their significant roles in biological and physiological processes, where even slight concentration variations can have major consequences. The article reviews literature from 2017 to 2024, highlighting advancements in the synthesis of 1,2,3-triazole-based ligands and their application (along with sensing mechanism) for detection of various ions causing health and environmental hazards. The detection aspects have been discussed sequentially for the transition-, inner transition-, and the metals from the s or p block of the periodic table.