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多能白血病细胞K-562上Fc（IgG）受体的特征分析

Characterization of the Fc(IgG) receptor on the pluripotential leukaemia cell K-562.

作者信息

Ichiki A T, Wust C J, Lozzio C B

出版信息

Clin Exp Immunol. 1985 Jan;59(1):64-8.

PMID:3971599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577162/
Abstract

K-562 cells express an Fc receptor that is murine isotype IgG specific. The receptor was defined by rosette formation using sheep erythrocytes sensitized with murine monoclonal haemagglutinin (EA) of known isotype. Optimal rosette formation occurred at 4 degrees C or ambient temperature; however, the number of rosettes formed at ambient temperature decreased after 8 h whereas formed rosettes were stable at 4 degrees C. EA in which IgG2b was the immunoglobulin isotype gave high numbers of rosettes while IgG2a gave lower but significant numbers. Aggregated human IgG inhibited rosette formation of EA(IgG2a) more easily than those of EA(IgG2b), indicating a higher affinity of the Fc receptor for IgG2b.

摘要

K-562细胞表达一种对鼠类同型IgG具有特异性的Fc受体。该受体通过使用用已知同型的鼠单克隆血凝素（EA）致敏的绵羊红细胞形成玫瑰花结来定义。最佳玫瑰花结形成发生在4℃或环境温度下；然而，在环境温度下形成的玫瑰花结数量在8小时后减少，而在4℃下形成的玫瑰花结是稳定的。以IgG2b为免疫球蛋白同型的EA产生大量玫瑰花结，而IgG2a产生的玫瑰花结数量较少但也很显著。聚集的人IgG比EA（IgG2a）更容易抑制EA（IgG2b）的玫瑰花结形成，表明Fc受体对IgG2b具有更高的亲和力。

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本文引用的文献

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J Exp Med. 1981 Mar 1;153(3):514-9. doi: 10.1084/jem.153.3.514.
2
A multipotential leukemia cell line (K-562) of human origin.一种源自人类的多能白血病细胞系（K-562）。
Proc Soc Exp Biol Med. 1981 Apr;166(4):546-50. doi: 10.3181/00379727-166-41106.
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Antibody-dependent cytolysis of the human leukemia cell line K-562 in the absence of effector cells or complement.
Blood. 1982 Jan;59(1):133-40.
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Characterization and function of T cell Fc gamma receptor.T细胞Fcγ受体的特性与功能
Immunol Rev. 1981;56:51-88. doi: 10.1111/j.1600-065x.1981.tb01047.x.
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Characterization of the Fc receptor for IgG on a human macrophage cell line, U937.人巨噬细胞系U937上IgG的Fc受体的特性分析。
J Immunol. 1980 Dec;125(6):2735-41.
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Fc receptors of a human promyelocytic leukemic cell line: evidence for two types of receptors defined by binding of the staphylococcal protein A-IgG1 complex.一种人早幼粒细胞白血病细胞系的Fc受体：通过葡萄球菌蛋白A-IgG1复合物结合定义的两种受体类型的证据。
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The Fc-receptor: its role in the transmission of differentiation signals.Fc受体：其在分化信号传递中的作用。
Immunol Rev. 1980;49:61-78. doi: 10.1111/j.1600-065x.1980.tb00426.x.
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Simultaneous interaction of monoclonal antibody-targeted liposomes with two receptors on K562 cells.
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