哮喘中的自然杀伤细胞活性。
Natural killer cell activity in asthma.
作者信息
Timonen T, Stenius-Aarniala B
出版信息
Clin Exp Immunol. 1985 Jan;59(1):85-90.
Abstract
Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centrifugation suggested that large granular lymphocytes (LGL) were the main mediators of the NK activity in asthmatics. Based on the lytic unit calculations, the strong NK activity in asthmatics is mainly due to increased frequency of LGL in peripheral blood rather than activity of individual NK cells.
摘要
对32名哮喘患者和13名对照供血者的外周血自然杀伤（NK）活性进行了分析。患有特应性哮喘的男性和女性患者对白血病细胞系K-562具有显著更强的NK活性。通过不连续密度梯度离心对患者单核细胞进行分离，结果表明大颗粒淋巴细胞（LGL）是哮喘患者NK活性的主要介导者。基于裂解单位计算，哮喘患者较强的NK活性主要是由于外周血中LGL频率增加，而非单个NK细胞的活性增强。
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本文引用的文献
1
Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity.体内自然杀伤活性的调节。II. 饮酒对人外周血自然杀伤活性的影响。
Int J Cancer. 1980 Oct 15;26(4):413-7. doi: 10.1002/ijc.2910260405.
2
Cell-mediated cytotoxicity against skin fibroblasts in atopic dermatitis.
J Immunol. 1982 Apr;128(4):1736-41.
3
Natural killer cells: their roles in defenses against disease.自然杀伤细胞：它们在抵御疾病中的作用。
Science. 1981 Oct 2;214(4516):24-30. doi: 10.1126/science.7025208.
4
Isolation of human and rat natural killer cells.人及大鼠自然杀伤细胞的分离
J Immunol Methods. 1982;51(3):269-77. doi: 10.1016/0022-1759(82)90393-3.
5
A new immunodeficiency disorder in humans involving NK cells.一种涉及自然杀伤细胞的人类新型免疫缺陷疾病。
Nature. 1980 Apr 10;284(5756):553-5. doi: 10.1038/284553a0.
6
Natural killer activity in the rat. IV. Distribution of large granular lymphocytes (LGL) following intravenous and intraperitoneal transfer.
Cell Immunol. 1984 Jul;86(2):371-80. doi: 10.1016/0008-8749(84)90392-7.
7
Leukotriene B4 augments human natural cytotoxic cell activity.白三烯B4增强人类自然细胞毒性细胞活性。
Biochem Biophys Res Commun. 1983 Jun 15;113(2):531-7. doi: 10.1016/0006-291x(83)91758-8.
8
The biology of the human natural killer cell.人类自然杀伤细胞的生物学特性。
J Clin Immunol. 1982 Oct;2(4):249-63. doi: 10.1007/BF00915064.
9
Cyclic AMP metabolism in asthma: studies with leukocytes and lymphocytes.哮喘中环状腺苷单磷酸代谢：白细胞和淋巴细胞研究
J Allergy Clin Immunol. 1974 Jan;53(1):27-33. doi: 10.1016/0091-6749(74)90096-7.
10
Mortality from malignant disease in patients with asthma.
Lancet. 1974 Dec 21;2(7895):1475-7. doi: 10.1016/s0140-6736(74)90217-7.
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