Chen Luo-Bei, Chen Qian, Chao Sheng, Yuan Zhi-Hui, Jia Lei, Niu Yu-Lin
Department of Organ Transplantation, Affiliated Hospital of Guizhou Medical University, No. 28 Guimedical Street, Yunyan District, Guiyang, Guizhou Province, 550000, China.
BMC Nephrol. 2024 Dec 23;25(1):468. doi: 10.1186/s12882-024-03899-y.
Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.
移植后糖尿病（PTDM）是肾移植术后常见的并发症，近年来其发病率呈逐渐上升趋势，对公共卫生构成了重大挑战。管理PTDM很复杂，因为研究表明它涉及多个器官微生物群的变化。最近的研究强调了肠道菌群代谢在肾移植后患者糖尿病发生中的关键作用。本文综述了PTDM患者肠道菌群的变化，并探讨了肠道菌群如何影响PTDM。这些发现可能为针对肠道菌群代谢产物预防和治疗PTDM提供新的视角。
