Yang Enhui, Chen Feng, Yang Yang, Zhang Yuansi, Lin Hao, Zhang Yu, Chu Maoping
Department of Child Healthcare, Wenzhou People's Hospital, Wenzhou, China.
Children's Heart Center, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
BMC Psychiatry. 2024 Dec 23;24(1):943. doi: 10.1186/s12888-024-06419-2.
To analyze the trend changes in the disease burden of depressive disorder (DD) among youth and adolescents aged 10 to 29 years globally from 1990 to 2021 to provide a theoretical basis for the prevention and treatment of DD in young populations. Utilizing data from the Global Burden of Disease Study 2021, prevalence rates and disability-adjusted life years (DALYs) were employed as indicators. Trends in the disease burden of DD among global youth aged 10 to 29 years from 1990 to 2021 were analyzed with joinpoint regression models. The analysis incorporated major risk factors. Concurrently, an age-period-cohort model was used to provide a more comprehensive assessment of the prevalence and burden of DD. Over the past 30 years, the prevalence rates of DD and DALYs rate among the 10-29-year-old age group generally showed an increasing trend, with values for females being consistently higher than values for males. Notably, compared with the other age groups, the 10- to 14- year-old age group presented more significant increases in both prevalence and DALYs. Regional disparity analysis revealed that while high-sociodemographic index (SDI) regions showed an increasing trend in DD prevalence and DALYs, middle- to low-SDI regions showed some decline. This study highlights the global disease burden of depressive disorder among young populations. The significant increase in both prevalence and DALYs in the 10- to 14-year-old age group emphasizes the trend toward an earlier onset of depressive disorder, also underlining the disparities in depressive disorder management between high-SDI and low-SDI regions. Clinical trial number: not applicable.
分析1990年至2021年全球10至29岁青少年和青年抑郁障碍（DD）疾病负担的趋势变化，为青年人群DD的预防和治疗提供理论依据。利用全球疾病负担研究2021年的数据，采用患病率和伤残调整生命年（DALYs）作为指标。使用Joinpoint回归模型分析了1990年至2021年全球10至29岁青年中DD疾病负担的趋势。该分析纳入了主要风险因素。同时，使用年龄-时期-队列模型对DD的患病率和负担进行更全面的评估。在过去30年中，10至29岁年龄组的DD患病率和DALYs率总体呈上升趋势，女性的值始终高于男性。值得注意的是，与其他年龄组相比，10至14岁年龄组的患病率和DALYs的增长更为显著。区域差异分析显示，虽然高社会人口学指数（SDI）地区的DD患病率和DALYs呈上升趋势，但中低SDI地区则有所下降。本研究突出了青年人群中抑郁障碍的全球疾病负担。10至14岁年龄组的患病率和DALYs均显著增加，强调了抑郁障碍发病年龄提前的趋势，也凸显了高SDI和低SDI地区在抑郁障碍管理方面的差异。临床试验编号：不适用。
