Hou Huifang, Zheng Miaoyun, Pan Kai, Wang Guodong, Li Zongjin, Li Qiong
Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, PR China.
Sanquan Medical College, Xinxiang Medical University, Xinxiang, PR China.
Histol Histopathol. 2025 Jul;40(7):993-1003. doi: 10.14670/HH-18-859. Epub 2024 Dec 5.
Extracellular adenine nucleotides serve as crucial signaling molecules and influence a broad spectrum of physiological and pathological processes. CD73, the rate-limiting enzyme in the metabolism of extracellular adenine nucleotides, is ubiquitously expressed on various cell types, particularly stem cells. CD73 mesenchymal stem cells (MSCs) have emerged as promising candidates for therapeutic applications due to their immunomodulatory and pro-regenerative properties. Numerous studies have highlighted the crucial role of CD73 in mediating tissue protection in myocardial infarction (MI). In this review, a brief overview of the cell type-specific expression, regulatory effects of CD73 on MSCs, and proangiogenic and immunomodulatory mechanisms is provided, with a focus on current findings concerning the protective functions of CD73 in the context of MI within the framework of stem cell therapy.
细胞外腺嘌呤核苷酸作为关键的信号分子，影响广泛的生理和病理过程。CD73是细胞外腺嘌呤核苷酸代谢的限速酶，在各种细胞类型，特别是干细胞上普遍表达。CD73间充质干细胞（MSCs）因其免疫调节和促再生特性，已成为有前景的治疗应用候选者。大量研究强调了CD73在介导心肌梗死（MI）组织保护中的关键作用。在本综述中，简要概述了CD73的细胞类型特异性表达、对MSCs的调节作用以及促血管生成和免疫调节机制，重点关注在干细胞治疗框架内关于CD73在MI背景下保护功能的当前研究结果。
