Feigin D S, Friedman P J, Liston S E, Haghighi P, Peters R M, Hill J G
J Comput Tomogr. 1985 Jan;9(1):21-32. doi: 10.1016/0149-936x(85)90046-3.
Four parameters of lymph node appearance on computed tomography were studied to improve specificity for malignancy in bronchogenic carcinoma: 1) node location, 2) homogeneity, 3) border definition, and 4) delineation by fat. Of 54 carcinoma patients, nodes were pathologically malignant in 21. Computed tomography showed enlarged nodes (over 1 cm) in 20 of these (true-positive rate, 96%), but also in 13 of the 33 patients with pathologically benign lymph nodes (false-positive rate, 39%). A combination of all four computed tomography parameters reduced the false-positive rate from 39 to 21% and decreased the true-positive rate from 96 to 86%. The criterion of border definition alone reduced the false-positive rate from 39 to 6%, but decreased the true-positive rate from 96 to 61%. The most useful computed tomography parameter was delineation, which reduced the false-positive rate to 15% and decreased the true-positive rate only to 86%. The computed tomography appearance of enlarged lymph nodes may be used to improve selection of patients with enlarged nodes for preoperative biopsy.
为提高对支气管源性癌中恶性肿瘤的特异性，研究了计算机断层扫描（CT）上淋巴结表现的四个参数：1）淋巴结位置，2）均匀性，3）边界清晰度，4）脂肪勾勒。在54例癌症患者中，21例的淋巴结病理检查为恶性。CT显示其中20例（真阳性率96%）有肿大淋巴结（超过1厘米），但在33例病理检查为良性淋巴结的患者中也有13例出现肿大淋巴结（假阳性率39%）。将所有四个CT参数结合起来可将假阳性率从39%降至21%，真阳性率从96%降至86%。仅边界清晰度这一标准可将假阳性率从39%降至6%，但真阳性率从96%降至61%。最有用的CT参数是脂肪勾勒，它可将假阳性率降至15%，真阳性率仅降至86%。肿大淋巴结的CT表现可用于改善对肿大淋巴结患者进行术前活检的选择。
