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小儿眼眶高级别B细胞淋巴瘤：一例报告并文献复习

Pediatric Orbital High-Grade B-Cell Lymphoma: A Case Report and Review of the Literature.

作者信息

Nguyen Kimberly K, Regner Michael F, Olson Susan B, Ng John D

机构信息

Department of Ophthalmology.

Department of Oculofacial Plastic, Orbital and Reconstructive Surgery, Casey Eye Institute.

出版信息

Ophthalmic Plast Reconstr Surg. 2025;41(4):e120-e122. doi: 10.1097/IOP.0000000000002885. Epub 2024 Dec 24.

DOI:10.1097/IOP.0000000000002885
PMID:39718145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12185768/
Abstract

Ocular involvement of lymphoma may present as a primary orbital or intraocular lymphoma or as a manifestation of metastatic disease. Involvement of various ocular structures may be difficult to diagnose due to its rarity and nonspecific clinical presentation. Primary high-grade B-cell lymphoma with MYC and BCL2 rearrangements of the orbit has rarely been reported in the adult population and has not previously been reported in the pediatric population. Herein the authors present a unique case of orbital high-grade B-cell lymphoma in a pediatric patient, initially diagnosed as preseptal cellulitis. Careful observation and escalation of care ultimately led to the accurate diagnosis and complete remission of the disease.

摘要

淋巴瘤累及眼部可表现为原发性眼眶或眼内淋巴瘤，或作为转移性疾病的一种表现。由于其罕见性和非特异性临床表现，累及各种眼部结构可能难以诊断。眼眶原发性伴有MYC和BCL2重排的高级别B细胞淋巴瘤在成人中鲜有报道，此前在儿科人群中尚未见报道。在此，作者报告了一例儿科患者眼眶高级别B细胞淋巴瘤的独特病例，该患者最初被诊断为睑前蜂窝织炎。仔细观察和加强治疗最终实现了疾病的准确诊断和完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/fce61999d339/nihms-2036465-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/5b1caa4eb91d/nihms-2036465-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/4305b507dd01/nihms-2036465-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/fce61999d339/nihms-2036465-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/5b1caa4eb91d/nihms-2036465-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/4305b507dd01/nihms-2036465-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeeb/12185768/fce61999d339/nihms-2036465-f0003.jpg

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本文引用的文献

1
Double-hit and triple-hit high-grade B-cell lymphoma of the ocular adnexa.眼部附属器的双打击和三打击高级 B 细胞淋巴瘤。
Orbit. 2022 Oct;41(5):624-628. doi: 10.1080/01676830.2021.1904426. Epub 2021 Mar 29.
2
Paediatric ocular adnexal lymphoma: a population-based analysis.儿童眼附属器淋巴瘤：一项基于人群的分析。
BMJ Open Ophthalmol. 2020 Jun 21;5(1):e000483. doi: 10.1136/bmjophth-2020-000483. eCollection 2020.
3
Triple-hit lymphoma of the cavernous sinus.
Can J Ophthalmol. 2019 Apr;54(2):e61-e66. doi: 10.1016/j.jcjo.2018.06.007. Epub 2018 Aug 28.
4
A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma.一例罕见的伴有眼眶侵犯的孤立性单灶性朗格汉斯细胞组织细胞增多症：诊断困境。
Oman J Ophthalmol. 2018 Sep-Dec;11(3):284-287. doi: 10.4103/ojo.OJO_149_2017.
5
Orbital lymphoma.眼眶淋巴瘤。
Surv Ophthalmol. 2019 Jan-Feb;64(1):45-66. doi: 10.1016/j.survophthal.2018.08.002. Epub 2018 Aug 23.
6
Isolated orbital mass as the primary presentation of a triple-hit lymphoma transformed from a systemic follicular lymphoma.孤立性眼眶肿物作为系统性滤泡性淋巴瘤转化而来的三打击淋巴瘤的主要表现。
Am J Ophthalmol Case Rep. 2018 Feb 24;10:156-158. doi: 10.1016/j.ajoc.2018.02.012. eCollection 2018 Jun.
7
Ocular adnexal diffuse large B-cell lymphoma: a multicenter international study.眼附属器弥漫性大B细胞淋巴瘤：一项多中心国际研究。
JAMA Ophthalmol. 2015 Feb;133(2):165-73. doi: 10.1001/jamaophthalmol.2014.4644.