Guo Ting, Li Wenyu, Zheng Wenjun, Lin Youkun, Wen Sijian
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun;398(6):7155-7170. doi: 10.1007/s00210-024-03742-z. Epub 2024 Dec 24.
The management of hair loss is vital in clinical dermatology due to its prevalence and impact on patients' quality of life. Quercetin is recognized for its diverse activities, including anti-inflammatory, anti-cancer, and immune regulation. However, its effects on human hair follicles and mechanisms remain unclear. This study explored quercetin's impact on countering DHT-induced cell damage, emphasizing apoptosis, cell cycle, mitochondria, and autophagy. Quercetin mitigated DHT's harm, restoring dermal papilla cell function and modulating cell cycle proteins. It restrained DHT-induced ROS and ATP loss, preserving mitochondrial integrity. Through network pharmacology analysis, it was discovered that quercetin targets SHP2, thereby regulating AKT signaling. Additionally, in mice, quercetin was found to promote hair growth. These significant insights highlight the potential of quercetin as a promising solution for hair loss and hair regeneration.
由于脱发的普遍性及其对患者生活质量的影响，脱发的管理在临床皮肤病学中至关重要。槲皮素因其多种活性而被认可，包括抗炎、抗癌和免疫调节。然而，其对人类毛囊的影响及其机制仍不清楚。本研究探讨了槲皮素对对抗双氢睾酮（DHT）诱导的细胞损伤的影响，重点关注细胞凋亡、细胞周期、线粒体和自噬。槲皮素减轻了DHT的损害，恢复了真皮乳头细胞功能并调节细胞周期蛋白。它抑制了DHT诱导的活性氧（ROS）和三磷酸腺苷（ATP）损失，维持了线粒体的完整性。通过网络药理学分析，发现槲皮素靶向含Src同源2结构域蛋白酪氨酸磷酸酶2（SHP2），从而调节蛋白激酶B（AKT）信号传导。此外，在小鼠中，发现槲皮素可促进头发生长。这些重要发现凸显了槲皮素作为脱发和毛发再生的一种有前景的解决方案的潜力。
