Downing S J, Sherwood O D
Endocrinology. 1985 Mar;116(3):1215-20. doi: 10.1210/endo-116-3-1215.
Cervices from day 18 (D18) intact pregnant rats show significantly greater extensibility and ability to accommodate to extension than cervices from D9 pregnant rats. On D22, cervices from intact pregnant rats show even greater extensibility and accommodation to stretch. Cervices from ovariectomized pregnant rats treated with estrogen (E) and progesterone (P; group OPE) show markedly reduced extensibility and ability to accommodate to stretch compared with intact pregnant cervical tissue (group C) on both D18 and D22. Extensibility of group OPE cervices resembles that of cervices from D9 intact pregnant rats. Cervices from ovariectomized pregnant rats treated with E, porcine relaxin (R), and P (group OPER) or porcine R and P (group OPR) exhibit similar extensibility and ability to accommodate to stretch as cervices from intact pregnant rats on both D18 and D22. The importance of R for cervical softening during pregnancy and its interaction with E near term and during parturition are discussed.
妊娠第18天（D18）的未切除卵巢的妊娠大鼠的子宫颈比妊娠第9天的妊娠大鼠的子宫颈表现出显著更大的伸展性和伸展适应能力。在D22时，未切除卵巢的妊娠大鼠的子宫颈表现出更大的伸展性和伸展适应能力。与D18和D22时未切除卵巢的妊娠子宫颈组织（C组）相比，用雌激素（E）和孕酮（P；OPE组）处理的切除卵巢的妊娠大鼠的子宫颈的伸展性和伸展适应能力明显降低。OPE组子宫颈的伸展性与D9未切除卵巢的妊娠大鼠的子宫颈相似。在D18和D22时，用E、猪松弛素（R）和P处理的切除卵巢的妊娠大鼠的子宫颈（OPER组）或用猪R和P处理的切除卵巢的妊娠大鼠的子宫颈（OPR组）与未切除卵巢的妊娠大鼠的子宫颈表现出相似的伸展性和伸展适应能力。本文讨论了R在妊娠期间子宫颈软化中的重要性及其在妊娠晚期和分娩期间与E的相互作用。
