Lymangrover J R, Buckalew V M, Harris J, Klein M C, Gruber K A
Endocrinology. 1985 Mar;116(3):1227-9. doi: 10.1210/endo-116-3-1227.
Previous reports suggest that peptides containing an amino acid sequence similar to that of ACTH-(4-10) increased Na excretion in the rat. gamma 2MSH contains such a sequence. An in vivo rat bioassay for natriuretic factors was employed to demonstrate the natriuretic action of gamma 2MSH. A significant natriuretic effect was observed, with a peak response 30-50 min following the bolus injections of 0.64, 6.4 or 64 pmol, but not with smaller or larger amounts of gamma 2MSH. A kaliuretic and diuretic action of gamma 2MSH was not consistently evident. gamma MSH may represent an endogenous compound involved in the physiological regulation of Na excretion.
先前的报告表明，含有与促肾上腺皮质激素-（4-10）氨基酸序列相似的肽可增加大鼠的钠排泄。γ2促黑素含有这样的序列。采用大鼠体内利尿因子生物测定法来证明γ2促黑素的利尿作用。观察到显著的利尿作用，在静脉推注0.64、6.4或64皮摩尔γ2促黑素后30-50分钟出现峰值反应，但较小或较大剂量的γ2促黑素则未出现此现象。γ2促黑素的排钾和利尿作用并不始终明显。γ促黑素可能是参与钠排泄生理调节的内源性化合物。
