Kim Eun-Hye, Wahl Katelyn, Guelfi Erica, Lee DaeYong
Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA.
Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA.
J Control Release. 2025 Feb 10;378:814-830. doi: 10.1016/j.jconrel.2024.12.046. Epub 2024 Dec 31.
It has recently been recognized that the physical characteristics of biomaterials - such as size, structure, shape, charge, mechanical strength, hydrophobicity, and multivalency - regulate immunological functions in innate immune cells. In immuno-oncology applications, biomaterials are engineered with distinct physical properties to achieve desired innate immune responses. In this review, we discuss how physical characteristics influence effector functions and innate immune signaling pathways in distinct innate immune cell subtypes. We highlight how physical properties of biomaterials impact phagocytosis regulation, biodistribution, and innate immune cell targeting. We outline the recent advances in physical engineering of biomaterials that directly or indirectly induce desired innate immune responses for cancer immunotherapy. Lastly, we discuss the challenges in current biomaterial approaches that need to be addressed to improve clinical applicability.
最近人们认识到，生物材料的物理特性——如尺寸、结构、形状、电荷、机械强度、疏水性和多价性——可调节固有免疫细胞中的免疫功能。在免疫肿瘤学应用中，生物材料被设计成具有独特的物理特性，以实现所需的固有免疫反应。在这篇综述中，我们讨论了物理特性如何影响不同固有免疫细胞亚型中的效应器功能和固有免疫信号通路。我们强调了生物材料的物理特性如何影响吞噬作用调节、生物分布和固有免疫细胞靶向。我们概述了生物材料物理工程的最新进展，这些进展直接或间接诱导了用于癌症免疫治疗的所需固有免疫反应。最后，我们讨论了当前生物材料方法中需要解决的挑战，以提高临床适用性。
