Zhao Peisen, Yang Yuwei, Yu Lingxue, Li Guoxin, Zhu Dandan
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Gels. 2025 Jun 18;11(6):468. doi: 10.3390/gels11060468.
This review examines the potential and challenges of using hydrogel vaccine delivery systems in animal immunization. Traditional methods face issues like low immunogenicity, reliance on cold chains, and inefficient delivery, limiting their use in modern animal husbandry. Hydrogels offer a promising solution due to their biocompatibility, controlled drug release, and immune regulation. This paper highlights hydrogels' benefits, such as mimicking natural infection through sustained antigen release, boosting antigen-presenting cell activity, activating immune responses, and forming barriers at mucosal sites to prevent pathogen invasion. Additionally, innovative delivery methods like microneedle patches and nasal sprays show promise in enhancing convenience and compliance in animal vaccination. By combining interdisciplinary efforts and technological advancements, the hydrogel vaccine delivery system is anticipated to be crucial in preventing animal diseases, supporting sustainable animal husbandry, and ensuring global animal health and food safety.
本综述探讨了水凝胶疫苗递送系统在动物免疫中的潜力和挑战。传统方法面临免疫原性低、依赖冷链和递送效率低下等问题，限制了它们在现代畜牧业中的应用。由于水凝胶具有生物相容性、可控药物释放和免疫调节作用，因此提供了一个有前景的解决方案。本文强调了水凝胶的益处，例如通过持续释放抗原来模拟自然感染、增强抗原呈递细胞活性、激活免疫反应以及在粘膜部位形成屏障以防止病原体入侵。此外，微针贴片和鼻喷雾剂等创新递送方法在提高动物疫苗接种的便利性和依从性方面显示出前景。通过跨学科努力和技术进步相结合，水凝胶疫苗递送系统有望在预防动物疾病、支持可持续畜牧业以及确保全球动物健康和食品安全方面发挥关键作用。
