Morris Richard G M
Edinburgh Neuroscience, University of Edinburgh, Edinburgh, UK.
Hippocampus. 2025 Jan;35(1):e23672. doi: 10.1002/hipo.23672.
As requested by the editors of this special issue of Hippocampus on Scientific Histories of Hippocampal Research, this review provides a detailed personal perspective and historical background on the research involved in a number of findings. The review includes description of the development of the water maze and its use in providing evidence to support the role of the hippocampus in spatial memory function. The review also describes how the water maze was then used in further work to support the proposal that NMDA-dependent synaptic modification in the hippocampus mediates the encoding of new spatial memories. This personal history gives a perspective on the convergence of different streams of physiological, biochemical, theoretical and behavioral research that resulted in these findings on hippocampal function.
应《海马体》关于海马体研究科学史这一特刊编辑的要求，本综述提供了对一系列研究发现所涉研究的详细个人观点和历史背景。该综述包括对水迷宫的发展及其在为支持海马体在空间记忆功能中的作用提供证据方面的应用的描述。该综述还描述了水迷宫随后如何在进一步的研究中被用于支持海马体中依赖NMDA的突触修饰介导新空间记忆编码的提议。这段个人经历为导致这些海马体功能研究发现的不同生理、生化、理论和行为研究流派的融合提供了一个视角。
