Li Xinhao, Zhou Feilong, Niu Kaiyi, Wang Yizhu, Shi Yanlong, Li Yunxin, Gao Xin, Zhao Weijie, Chen Tianyi, Zhang Yewei
Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Cell Death Discov. 2024 Dec 24;10(1):513. doi: 10.1038/s41420-024-02276-w.
TRIM14 is an important member of the TRIM family and is widely expressed in a variety of tissues. Like other members of the TRIM family, TRIM14 is also involved in ubiquitination modifications. TRIM14 was initially reported as an interferon-stimulated gene (ISG). In recent years, many studies have focused on the regulatory role of TRIM14 in signaling pathways such as the PI3K/Akt, NF-κB, and cGAS/STING pathways and revealed its mechanism of action in a variety of pathophysiological processes, and the regulation of TRIM14 has attracted the interest of many researchers as a new direction for the treatment of various diseases. However, there are no reviews on the role of TRIM14 in diseases. In this paper, we will describe the structure of TRIM14, review its role in cancer, cardiovascular disease, cervical spondylosis, inflammation and antiviral immunity, and provide an outlook on future research directions.
TRIM14是TRIM家族的重要成员，在多种组织中广泛表达。与TRIM家族的其他成员一样，TRIM14也参与泛素化修饰。TRIM14最初被报道为一种干扰素刺激基因（ISG）。近年来，许多研究聚焦于TRIM14在PI3K/Akt、NF-κB和cGAS/STING等信号通路中的调控作用，并揭示了其在多种病理生理过程中的作用机制，TRIM14的调控作为治疗各种疾病的新方向引起了众多研究人员的兴趣。然而，目前尚无关于TRIM14在疾病中作用的综述。在本文中，我们将描述TRIM14的结构，综述其在癌症、心血管疾病、颈椎病、炎症和抗病毒免疫中的作用，并对未来的研究方向进行展望。
