盐皮质激素受体拮抗剂除减少细胞外液量外可能具有的降压作用。 - Suppr

Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water.

作者信息

Morita Ryutaro, Wakui Hiromichi, Tamura Kouichi

机构信息

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

出版信息

Hypertens Res. 2025 Mar;48(3):1241-1243. doi: 10.1038/s41440-024-02075-x. Epub 2024 Dec 24.

DOI:10.1038/s41440-024-02075-x

PMID:39719533

Abstract

摘要

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Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water.盐皮质激素受体拮抗剂除减少细胞外液量外可能具有的降压作用。

Hypertens Res. 2025 Mar;48(3):1241-1243. doi: 10.1038/s41440-024-02075-x. Epub 2024 Dec 24.

Antihypertensive effects and changes in extracellular water content by mineralocorticoid receptor antagonists in patients with primary aldosteronism.盐皮质激素受体拮抗剂对原发性醛固酮增多症患者的降压作用及细胞外液含量变化

Hypertens Res. 2025 Feb;48(2):553-562. doi: 10.1038/s41440-024-01997-w. Epub 2024 Nov 14.

Primary Aldosteronism and the Role of Mineralocorticoid Receptor Antagonists for the Heart and Kidneys.原发性醛固酮增多症与醛固酮受体拮抗剂在心脏和肾脏中的作用。

Annu Rev Med. 2023 Jan 27;74:217-230. doi: 10.1146/annurev-med-042921-100438. Epub 2022 Nov 14.

Recent progress in the diagnosis and treatment of primary aldosteronism.原发性醛固酮增多症的诊治进展。

Hypertens Res. 2023 Jul;46(7):1738-1744. doi: 10.1038/s41440-023-01288-w. Epub 2023 May 17.

Effectiveness of nonsteroidal mineralocorticoid receptor antagonists in patients with diabetic kidney disease.非甾体类盐皮质激素受体拮抗剂在糖尿病肾病患者中的疗效

Postgrad Med. 2023 Apr;135(3):224-233. doi: 10.1080/00325481.2022.2060598. Epub 2022 Apr 20.

Mineralocorticoid Receptor Antagonists Decrease the Rates of Positive Screening for Primary Aldosteronism.醛固酮受体拮抗剂降低原发性醛固酮增多症阳性筛查率。

Endocr Pract. 2020 Dec;26(12):1416-1424. doi: 10.4158/EP-2020-0277.

Mineralocorticoid Receptor Antagonists and Clinical Outcomes in Primary Aldosteronism: As Good as Surgery?原发性醛固酮增多症中盐皮质激素受体拮抗剂与临床结局：与手术效果相当？

Horm Metab Res. 2015 Dec;47(13):1000-6. doi: 10.1055/s-0035-1565128. Epub 2015 Dec 14.

Evolution of mineralocorticoid receptor antagonists, aldosterone synthase inhibitors, and alternative treatments for managing primary aldosteronism.盐皮质激素受体拮抗剂、醛固酮合酶抑制剂的演变以及原发性醛固酮增多症的替代治疗方法。

Hypertens Res. 2025 Feb;48(2):854-861. doi: 10.1038/s41440-024-01970-7. Epub 2024 Nov 29.

Progress in primary aldosteronism: mineralocorticoid receptor antagonists and management of primary aldosteronism in pregnancy.原发性醛固酮增多症的进展：盐皮质激素受体拮抗剂与妊娠合并原发性醛固酮增多症的管理

Eur J Endocrinol. 2015 Jan;172(1):R23-30. doi: 10.1530/EJE-14-0444. Epub 2014 Aug 27.

Quality of Life of Primary Aldosteronism Patients by Mineralocorticoid Receptor Antagonists.盐皮质激素受体拮抗剂对原发性醛固酮增多症患者生活质量的影响

J Endocr Soc. 2021 Feb 16;5(4):bvab020. doi: 10.1210/jendso/bvab020. eCollection 2021 Apr 1.

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Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.微管与机械传感：内皮细胞对机械刺激作出反应的关键因素

Cell Mol Life Sci. 2025 Aug 21;82(1):317. doi: 10.1007/s00018-025-05828-0.

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High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment.高患病率的衰弱在患有肾上腺腺瘤和肾上腺皮质激素过多症的患者：一个横断面多中心前瞻性研究。

Eur J Endocrinol. 2023 Sep 1;189(3):318-326. doi: 10.1093/ejendo/lvad113.

The relationship between extracellular water-to-body water ratio and sarcopenia according to the newly revised Asian Working Group for Sarcopenia: 2019 Consensus Update.根据新修订的亚洲肌少症工作组定义：2019 年共识更新，细胞外液与体水比与肌少症的关系。

Aging Clin Exp Res. 2021 Sep;33(9):2471-2477. doi: 10.1007/s40520-020-01766-y. Epub 2021 Jan 17.

Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.在原发性醛固酮增多症患者中，肾功能损害与血浆醛固酮浓度密切相关。

Eur J Endocrinol. 2019 Sep;181(3):339-350. doi: 10.1530/EJE-19-0047.

Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan.原发性醛固酮增多症患者中心血管疾病及其危险因素的流行情况：日本多中心研究。

Hypertension. 2018 Mar;71(3):530-537. doi: 10.1161/HYPERTENSIONAHA.117.10263. Epub 2018 Jan 22.

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors.平滑肌细胞盐皮质激素受体对血压的直接调节。

Nat Med. 2012 Sep;18(9):1429-33. doi: 10.1038/nm.2891.

Aldosterone induces myocyte apoptosis in the heart and skeletal muscles of rats in vivo.醛固酮在体内可诱导大鼠心脏和骨骼肌中的心肌细胞凋亡。

J Mol Cell Cardiol. 2005 Aug;39(2):395-9. doi: 10.1016/j.yjmcc.2005.04.001.

Distinguishing the antihypertensive and electrolyte effects of eplerenone.区分依普利酮的降压作用和电解质效应。

J Clin Endocrinol Metab. 2004 Jun;89(6):2736-40. doi: 10.1210/jc.2003-032149.

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.依普利酮，一种选择性醛固酮阻滞剂，用于心肌梗死后左心室功能不全的患者。

N Engl J Med. 2003 Apr 3;348(14):1309-21. doi: 10.1056/NEJMoa030207. Epub 2003 Mar 31.

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.螺内酯对重度心力衰竭患者发病率和死亡率的影响。随机螺内酯评估研究调查组。

N Engl J Med. 1999 Sep 2;341(10):709-17. doi: 10.1056/NEJM199909023411001.

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Possible antihypertensive effects of mineralocorticoid receptor antagonists other than reducing extracellular water.

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