Komatsu Hiroshi, Sato Yutaro, Tomimoto Kazuho, Onoguchi Goh, Matsuki Tasuku, Hamaie Yumiko, Sakuma Atsushi, Ohmuro Noriyuki, Katsura Masahiro, Ito Fumiaki, Ono Takashi, Matsumoto Kazunori, Tomita Hiroaki
Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan; Miyagi Psychiatric Center, Natori, Miyagi, Japan.
Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan.
Asian J Psychiatr. 2025 Jan;103:104345. doi: 10.1016/j.ajp.2024.104345. Epub 2024 Dec 17.
Autistic symptoms in schizophrenia are reportedly associated with cognitive and social functions. However, few studies have investigated the association between autistic symptoms and clinical features in individuals with a clinical high risk for psychosis (CHR-P) and first-episode psychosis (FEP). We aimed to determine the association between autistic symptoms and clinical features in a cohort of individuals with CHR-P or FEP.
This cross-sectional study included 111 participants (CHR-P: 61, FEP: 50). Autistic symptoms were assessed using the Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale. We assessed the association between autistic symptoms and global and social functioning, and cognitive function in individuals with CHR-P or EFP. Multiple regression analysis was also performed using age and sex as covariates to determine the association between autistic symptoms and global functioning.
The participants with FEP had more severe autistic symptoms than those with CHR-P. The results of bivariate correlation analysis showed a significantly negative association of autistic symptoms with global and cognitive functions in both participants with CHR-P and those with FEP. Multiple regression analysis showed that sex, autistic symptoms, and positive symptoms were significant predictors of overall functioning in those participants.
These findings suggest that autistic symptoms are associated with lower global functioning with both individuals at CHR-P and those with FEP. Further longitudinal analysis is needed to characterize the association between autistic symptoms and global functioning in CHR-P and FEP.
据报道，精神分裂症中的自闭症症状与认知和社会功能有关。然而，很少有研究调查有精神病临床高危（CHR-P）和首发精神病（FEP）个体的自闭症症状与临床特征之间的关联。我们旨在确定一组CHR-P或FEP个体中自闭症症状与临床特征之间的关联。
这项横断面研究纳入了111名参与者（CHR-P：61名，FEP：50名）。使用精神分裂症自闭症严重程度量表的阳性和阴性综合征量表评估自闭症症状。我们评估了CHR-P或EFP个体中自闭症症状与整体和社会功能以及认知功能之间的关联。还使用年龄和性别作为协变量进行多元回归分析，以确定自闭症症状与整体功能之间的关联。
FEP参与者的自闭症症状比CHR-P参与者更严重。双变量相关分析结果显示，CHR-P参与者和FEP参与者中，自闭症症状与整体和认知功能均呈显著负相关。多元回归分析表明，性别、自闭症症状和阳性症状是这些参与者整体功能的重要预测因素。
这些发现表明，自闭症症状与CHR-P个体和FEP个体的较低整体功能有关。需要进一步进行纵向分析，以明确CHR-P和FEP中自闭症症状与整体功能之间的关联。
