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一名乳腺癌患者的非进行性CRMP-5相关性中心凹周围视网膜病变:一种罕见的副肿瘤现象。

Non-progressive CRMP-5-Associated Perifoveal Retinopathy in a Breast Cancer Patient: A Rare Paraneoplastic Phenomenon.

作者信息

Canut Isabella, Bielling Rachel, Steinmetz Fiona, Esquivel Raquel, Maitland Charles

机构信息

Neurology, Philadelphia College of Osteopathic Medicine, Suwanee, USA.

Neurology, Florida State University College of Medicine, Tallahassee, USA.

出版信息

Cureus. 2024 Nov 24;16(11):e74342. doi: 10.7759/cureus.74342. eCollection 2024 Nov.

Abstract

Paraneoplastic retinopathy (PR) is a rare autoimmune condition typically associated with progressive visual loss and is often linked to anti-recoverin antibodies. Paraneoplastic optic neuropathy (PON) is classically associated with collapsin response-mediator protein (CRMP-5). We present a unique case of non-progressive CRMP-5-associated perifoveal retinitis in a 79-year-old female with a history of breast carcinoma, who has maintained a stable visual acuity over an extended follow-up period of three years.

摘要

副肿瘤性视网膜病变(PR)是一种罕见的自身免疫性疾病,通常与进行性视力丧失相关,且常与抗 recoverin 抗体有关。副肿瘤性视神经病变(PON)经典地与塌陷反应介导蛋白(CRMP-5)相关。我们报告了一例独特的病例,一名 79 岁有乳腺癌病史的女性患有非进行性 CRMP-5 相关的黄斑旁视网膜病变,在三年的长期随访期间视力保持稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4db/11668126/40ea4e0a589a/cureus-0016-00000074342-i01.jpg

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