Das Amlan, Bararia Akash, Mukherjee Sanghamitra, Sikdar Nilabja
Department of Biochemistry, Royal Global University, Guwahati 781035, India.
Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, India.
World J Clin Oncol. 2024 Dec 24;15(12):1459-1462. doi: 10.5306/wjco.v15.i12.1459.
The retrospective study by Lew (2022) examined the rising hospitalization rates for chronic pancreatitis (CP) and its association with pancreatic ductal adenocarcinoma (PDAC), revealing significant ethno-racial disparities and risk factors. Overweight black men aged 40-59 years and white men over 40 years with higher incomes showed an elevated risk of PDAC among CP patients. The study, which included 14.2 million admissions from 2016-2017, found that 2.6% of adult patients were diagnosed with CP, with white males being the majority. Multivariate regression analysis identified men, black individuals, those aged 40-59 years, and individuals with a body mass index (BMI) between 25 and 29.9 as having an increased risk for CP. Moreover, 0.78% of CP patients also had PDAC, with older age and BMI being significant risk factors for developing PDAC in CP patients. The study also highlighted disparities in healthcare access and utilization among different socioeconomic and ethno-racial groups, which may impact the risk and outcomes of CP and PDAC.
Lew（2022年）的回顾性研究调查了慢性胰腺炎（CP）住院率的上升及其与胰腺导管腺癌（PDAC）的关联，揭示了显著的种族差异和风险因素。40至59岁的超重黑人男性以及40岁以上收入较高的白人男性在CP患者中患PDAC的风险升高。该研究纳入了2016年至2017年的1420万例住院病例，发现2.6%的成年患者被诊断为CP，其中白人男性占多数。多变量回归分析确定男性、黑人、40至59岁的人群以及体重指数（BMI）在25至29.9之间的个体患CP的风险增加。此外，0.78%的CP患者也患有PDAC，年龄较大和BMI是CP患者发生PDAC的重要风险因素。该研究还强调了不同社会经济和种族群体在医疗保健获取和利用方面的差异，这可能会影响CP和PDAC的风险及治疗结果。
