Ma Xiaodong, Zhao Wenjian, Yang Fan, Chin Kok-Yong
Department of Traditional Chinese Medicine, Universiti Tunku Abdul Rahman, Kajang, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Malaysia; Department of Pathology, College of Basic Medicine, Xiangnan University, Chenzhou City, China.
Biomol Biomed. 2025 Mar 7;25(4):761-785. doi: 10.17305/bb.2024.11045.
Osteoarthritis (OA) is a degenerative joint disease that primarily affects the elderly worldwide. It is characterized by local inflammation, which can be targeted therapeutically using natural anti-inflammatory compounds such as curcumin. This scoping review explores the therapeutic effects and mechanisms of curcumin in OA management. A total of 50 relevant original studies published in English were selected from PubMed, Web of Science, and Scopus using specific search strings, regardless of study type. These studies demonstrated curcumin's anti-inflammatory, protective, and anti-apoptotic effects on chondrocytes. Curcumin has been shown to stimulate chondrocyte proliferation and collagen production while inhibiting matrix metalloproteinase activity. These mechanisms contribute to curcumin's ability to alleviate pain and improve joint function in OA patients. While the findings highlight curcumin's potential in OA management, further research is needed to enhance its bioavailability and determine optimal formulations, dosages, and administration routes.
骨关节炎（OA）是一种退行性关节疾病，主要影响全球的老年人。其特征是局部炎症，可以使用姜黄素等天然抗炎化合物进行靶向治疗。本综述探讨了姜黄素在骨关节炎管理中的治疗效果和机制。使用特定检索词从PubMed、Web of Science和Scopus中总共筛选出50项以英文发表的相关原始研究，不考虑研究类型。这些研究证明了姜黄素对软骨细胞具有抗炎、保护和抗凋亡作用。姜黄素已被证明可以刺激软骨细胞增殖和胶原蛋白生成，同时抑制基质金属蛋白酶活性。这些机制有助于姜黄素减轻骨关节炎患者的疼痛并改善关节功能。虽然研究结果突出了姜黄素在骨关节炎管理中的潜力，但仍需要进一步研究以提高其生物利用度，并确定最佳配方、剂量和给药途径。
