Li Muhan, Ma Tingting, Yin Xueke, Zhang Xin, Long Tenghai, Zeng Min, Wang Juan, Cui Qianyu, Li Shu, Sessler Daniel I, Wang Rong, Peng Yuming
Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
J Clin Anesth. 2025 Feb;101:111733. doi: 10.1016/j.jclinane.2024.111733. Epub 2024 Dec 24.
The cerebral oximetry index (CO) uses near-infrared spectroscopy to estimate cerebral autoregulation during cardiac surgery. However, the relationship between intraoperative loss of cerebral autoregulation and postoperative delirium or stroke remains unclear in patients recovering from carotid endarterectomy (CEA).
Our prospective observational cohort study enrolled patients scheduled for CEA. CO was estimated as the coefficient of a continuous, moving Spearman correlation between mean arterial pressure and cerebral oxygen saturation. A receiver operating characteristics curve with Youden's index identified the optimal CO threshold for predicting a composite of postoperative delirium or new-onset overt stroke.
One hundred and forty patients scheduled for CEA were enrolled. The incidence of delirium was 10.7 % (15/140) and the incidence of stroke was 3.6 % (5/140), including 1 patient who had both. The cumulative anesthesia time when CO exceeded 0.3 was longer in patients with complications than those without. When CO > 0.6, the corresponding predictive ability was AUC = 0.69, Youden index = 0.61, P = 0.0003, with a positive predictive value of 100 %. In the post hoc subgroup analyses, before clamping, the greatest increase in the risk was observed when CO > 0.7 for 20 min (Odds ratio = 3.10, 95 % CI 2.20, 3.78). In contrast, CO was not predictive during clamping. After clamping, the optimal CO threshold was 0.4 (AUC = 0.85, Youden index = 0.82, P < 0.0001), with the positive predictive value being 100 %.
CO is a promising metric for predicting postoperative delirium or new-onset overt stroke in patients having CEA. The optimal CO threshold was 0.7 in the pre-clamping phase and 0.4 in the post-clamping phase.
