• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy.解析广泛中和抗体：发热伴血小板减少综合征病毒治疗的一个里程碑。
EBioMedicine. 2025 Jan;111:105527. doi: 10.1016/j.ebiom.2024.105527. Epub 2024 Dec 24.
2
Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.从严重发热伴血小板减少综合征人类幸存者中发现并鉴定强效广谱中和抗体
EBioMedicine. 2025 Jan;111:105481. doi: 10.1016/j.ebiom.2024.105481. Epub 2024 Dec 6.
3
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.SFTSV 广谱中和抗体的分子机制和结构导向人源化。
PLoS Pathog. 2024 Sep 25;20(9):e1012550. doi: 10.1371/journal.ppat.1012550. eCollection 2024 Sep.
4
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.一种广泛保护性的针对糖蛋白 Gn 的抗体可抑制严重发热伴血小板减少综合征病毒感染。
Nat Commun. 2024 Aug 15;15(1):7009. doi: 10.1038/s41467-024-51108-z.
5
Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China.中国山东省一般人群中对发热伴血小板减少综合征病毒的中和抗体。
Sci Rep. 2018 Oct 18;8(1):15401. doi: 10.1038/s41598-018-33884-z.
6
Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines.严重发热伴血小板减少综合征病毒糖蛋白是中和抗体的靶标，可利用树突状细胞特异性细胞间黏附分子-3 捕获非整合素作为 pH 依赖性进入人和动物细胞系的受体。
J Virol. 2013 Apr;87(8):4384-94. doi: 10.1128/JVI.02628-12. Epub 2013 Feb 6.
7
Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge.人源单克隆抗体的配对组合可使小鼠完全抵御布尼亚病毒SFTSV的致死性攻击。
PLoS Pathog. 2025 Jan 31;21(1):e1012889. doi: 10.1371/journal.ppat.1012889. eCollection 2025 Jan.
8
[Preparation and functional analysis of the monoclonal antibodies against severe fever with thrombocytopenia syndrome bunyavirus structural proteins].抗发热伴血小板减少综合征布尼亚病毒结构蛋白单克隆抗体的制备及功能分析
Bing Du Xue Bao. 2015 Jan;31(1):18-23.
9
Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus.单剂量基于重组水疱性口炎病毒（rVSV）的疫苗可引发针对严重发热伴血小板减少综合征病毒的完全保护。
NPJ Vaccines. 2019 Jan 25;4:5. doi: 10.1038/s41541-018-0096-y. eCollection 2019.
10
Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses.鉴定和表征三种针对 SFTSV 糖蛋白的单克隆抗体，并显示对 SFTSV 相关病毒的广谱识别。
PLoS Negl Trop Dis. 2024 Jun 7;18(6):e0012216. doi: 10.1371/journal.pntd.0012216. eCollection 2024 Jun.

本文引用的文献

1
Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.从严重发热伴血小板减少综合征人类幸存者中发现并鉴定强效广谱中和抗体
EBioMedicine. 2025 Jan;111:105481. doi: 10.1016/j.ebiom.2024.105481. Epub 2024 Dec 6.
2
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.SFTSV 广谱中和抗体的分子机制和结构导向人源化。
PLoS Pathog. 2024 Sep 25;20(9):e1012550. doi: 10.1371/journal.ppat.1012550. eCollection 2024 Sep.
3
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.一种广泛保护性的针对糖蛋白 Gn 的抗体可抑制严重发热伴血小板减少综合征病毒感染。
Nat Commun. 2024 Aug 15;15(1):7009. doi: 10.1038/s41467-024-51108-z.
4
CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus.CCR2 是发热伴血小板减少综合征病毒的宿主进入受体。
Sci Adv. 2023 Aug 2;9(31):eadg6856. doi: 10.1126/sciadv.adg6856.
5
Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.抗裂谷热病毒人源单克隆抗体的中和机制。
Nat Microbiol. 2019 Jul;4(7):1231-1241. doi: 10.1038/s41564-019-0411-z. Epub 2019 Apr 1.
6
An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus.从恢复期患者中分离出的一种抗 Gn 糖蛋白抗体能有效抑制发热伴血小板减少综合征病毒感染。
PLoS Pathog. 2019 Feb 1;15(2):e1007375. doi: 10.1371/journal.ppat.1007375. eCollection 2019 Feb.
7
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.体液免疫应答缺陷和 B 细胞免疫紊乱与致命性发热伴血小板减少综合征病毒感染有关。
Nat Commun. 2018 Aug 20;9(1):3328. doi: 10.1038/s41467-018-05746-9.
8
A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.一种新型蜱传黄病毒，与发热伴血小板减少综合征病毒和 Heartland 病毒密切相关，是一种潜在的病原体。
Emerg Microbes Infect. 2018 May 25;7(1):95. doi: 10.1038/s41426-018-0093-2.
9
Human antibody neutralizes severe Fever with thrombocytopenia syndrome virus, an emerging hemorrhagic Fever virus.人类抗体可中和新型出血热病毒——严重发热伴血小板减少综合征病毒。
Clin Vaccine Immunol. 2013 Sep;20(9):1426-32. doi: 10.1128/CVI.00222-13. Epub 2013 Jul 17.
10
Fever with thrombocytopenia associated with a novel bunyavirus in China.中国发现一种新型布尼亚病毒所致发热伴血小板减少综合征
N Engl J Med. 2011 Apr 21;364(16):1523-32. doi: 10.1056/NEJMoa1010095. Epub 2011 Mar 16.

Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy.

作者信息

Zhao Xiaoyu, Chu Hin

机构信息

Shanghai Sci-Tech Inno Center for Infection & Immunity, National Medical Center for Infectious Diseases, Huashan Hospital, Institute of Infection and Health, Fudan University, Shanghai, China.

State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, China; Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China; Materials Innovation Institute for Life Sciences and Energy (MILES), HKU-SIRI, Shenzhen, China.

出版信息

EBioMedicine. 2025 Jan;111:105527. doi: 10.1016/j.ebiom.2024.105527. Epub 2024 Dec 24.

DOI:10.1016/j.ebiom.2024.105527
PMID:39721216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11732472/
Abstract
摘要