Decoding broadly neutralizing antibodies: a milestone in SFTSV therapy.
作者信息
Zhao Xiaoyu, Chu Hin
机构信息
Shanghai Sci-Tech Inno Center for Infection & Immunity, National Medical Center for Infectious Diseases, Huashan Hospital, Institute of Infection and Health, Fudan University, Shanghai, China.
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Hong Kong SAR, China; Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong Province, China; Materials Innovation Institute for Life Sciences and Energy (MILES), HKU-SIRI, Shenzhen, China.
出版信息
EBioMedicine. 2025 Jan;111:105527. doi: 10.1016/j.ebiom.2024.105527. Epub 2024 Dec 24.
Abstract
摘要
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本文引用的文献
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Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.从严重发热伴血小板减少综合征人类幸存者中发现并鉴定强效广谱中和抗体
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2
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV.SFTSV 广谱中和抗体的分子机制和结构导向人源化。
PLoS Pathog. 2024 Sep 25;20(9):e1012550. doi: 10.1371/journal.ppat.1012550. eCollection 2024 Sep.
3
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.一种广泛保护性的针对糖蛋白 Gn 的抗体可抑制严重发热伴血小板减少综合征病毒感染。
Nat Commun. 2024 Aug 15;15(1):7009. doi: 10.1038/s41467-024-51108-z.
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CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus.CCR2 是发热伴血小板减少综合征病毒的宿主进入受体。
Sci Adv. 2023 Aug 2;9(31):eadg6856. doi: 10.1126/sciadv.adg6856.
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Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.抗裂谷热病毒人源单克隆抗体的中和机制。
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PLoS Pathog. 2019 Feb 1;15(2):e1007375. doi: 10.1371/journal.ppat.1007375. eCollection 2019 Feb.
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