Xu Fenglan, Gao Yang, Xin Huan, Cao Chenxi, Ma Wenyuan, Sun Wentao, Ma Qingming
Department of Clinical Pharmacy, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China; School of Pharmacy, Qingdao University, Qingdao 266071, China.
Department of Pharmacy, Weifang People's Hospital, Weifang 261041, China; School of Pharmacy, Qingdao University, Qingdao 266071, China.
Int J Biol Macromol. 2025 Feb;290:139133. doi: 10.1016/j.ijbiomac.2024.139133. Epub 2024 Dec 23.
Recent progress in wound healing has highlighted the need for more effective treatment strategies capable of addressing the complex biological and physiological challenges of wound repair. Traditional wound dressings often fail to address the complex and evolving needs of chronic, acute, and burn wounds, particularly in terms of promoting healing, preventing infection, and supporting tissue regeneration. In response to these challenges, calcium alginate fibers (CAFs) have emerged as promising materials, characterized by their exceptional structural properties and diverse biological functions, offering significant commercial potential for the development of advanced wound dressings and therapeutic solutions. Here, a brief review of the CAFs for promoting wound healing is presented, with specific discussions of the fundamental characteristics of CAFs and its feasibility to be applied for adjusting physiological and pathological processes involved in wound healing. Then, a comprehensive and in-depth depiction of emerging representative fabrication techniques for generating CAFs is categorized and reviewed. Moreover, emerging applications benefits from the CAFs are reviewed, highlighting the multifunctional roles and benefits of CAFs in facilitating wound repair. Finally, the challenges and perspectives for further advancing CAFs toward a more powerful and versatile therapeutic strategy are discussed, particularly regarding new opportunities in biomedical research and clinical applications.
伤口愈合领域的最新进展凸显了对更有效治疗策略的需求，这些策略应能够应对伤口修复过程中复杂的生物学和生理学挑战。传统的伤口敷料往往无法满足慢性、急性和烧伤伤口复杂且不断变化的需求，尤其是在促进愈合、预防感染和支持组织再生方面。为应对这些挑战，海藻酸钙纤维（CAFs）已成为有前景的材料，其具有卓越的结构特性和多样的生物学功能，在先进伤口敷料和治疗解决方案的开发中具有巨大的商业潜力。在此，本文对用于促进伤口愈合的CAFs进行简要综述，具体讨论CAFs的基本特性及其应用于调节伤口愈合相关生理和病理过程的可行性。然后，对用于制备CAFs的新兴代表性制造技术进行分类和深入综述。此外，还综述了CAFs带来的新兴应用，强调了CAFs在促进伤口修复中的多功能作用和益处。最后，讨论了将CAFs进一步推进为更强大、更通用治疗策略面临的挑战和前景，特别是在生物医学研究和临床应用方面的新机遇。
