Wang Xiwen, Ni Tianyang, Miao Jianru, Huang Xinyao, Feng Zhe
The First Clinical Medical College, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, China.
The First Clinical Medical College, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Nanjing 210023, China.
Ageing Res Rev. 2025 Feb;104:102643. doi: 10.1016/j.arr.2024.102643. Epub 2024 Dec 24.
Triptolide (TP) is the primary pharmacological component of Tripterygium Glycosides (TG), which has anti-inflammatory, antiproliferative, and immunosuppressive properties, among other pharmacological actions, and has excellent potential for developing into a new DMARD. We have reviewed the effects and mechanisms of TP on immunosuppression, inhibiting synovial proliferation, and preventing articular bone destruction in the treatment of rheumatoid arthritis (RA), which is a common disease in the elderly in this paper. We have found that TP has regulatory effects on multiple vital cells in the above-mentioned pathological process of RA, such as monocytes/macrophages, dendritic cells, T cells, fibroblast-like synoviocytes, and osteoclasts. We also found that TP can regulate multiple key signaling pathways such as NF-κB, JAK/STAT, and MAPK through various molecular regulatory mechanisms, achieving regulatory effects on numerous phenotypes of the above-mentioned vital cells.
雷公藤甲素（TP）是雷公藤多苷（TG）的主要药理成分，具有抗炎、抗增殖和免疫抑制等多种药理作用，在开发新型改善病情抗风湿药方面具有巨大潜力。本文综述了TP在类风湿关节炎（RA，一种老年人常见疾病）治疗中对免疫抑制、抑制滑膜增殖及预防关节骨质破坏的作用和机制。我们发现TP在RA上述病理过程中对多种重要细胞具有调节作用，如单核细胞/巨噬细胞、树突状细胞、T细胞、成纤维样滑膜细胞和破骨细胞。我们还发现TP可通过多种分子调节机制调控NF-κB、JAK/STAT和MAPK等多条关键信号通路，对上述重要细胞的多种表型发挥调节作用。
