可溶性触发受体表达于髓系细胞2（sTREM2）的脑脊液水平是肌萎缩侧索硬化症的一种潜在生物标志物，并与上运动神经元负担相关。
sTREM2 cerebrospinal fluid levels are a potential biomarker in amyotrophic lateral sclerosis and associate with UMN burden.
作者信息
Jiao Lin, Yang Jing, Wang Wenjing, Liu Xiangyi, Fu Yu, Fan Dongsheng
机构信息
Department of Neurology, Peking University Third Hospital, Beijing, China.
Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, China.
出版信息
Front Neurol. 2024 Dec 10;15:1515252. doi: 10.3389/fneur.2024.1515252. eCollection 2024.
OBJECTIVES
The aims of this study were to investigate whether CSF sTREM2 may be a potential marker of disease monitoring for amyotrophic lateral sclerosis (ALS).
METHODS
We investigated whether CSF sTREM2 levels are altered in ALS patients and are correlated with upper motor neuron (UMN) burden and disease progression.
RESULTS
CSF sTREM2 was greater in the ALS patients than in the controls ( = 0.002). Elevated CSF sTREM2 was associated with the UMN score ( = 0.38, = 0.009), ΔFS ( = 0.30, = 0.04) and serum NFL (lg) ( = 0.35, = 0.015). As the motor band sign (MBS) score increased, the CSF sTREM2 level increased (-trend = 0.014). Furthermore, the correlations became stronger (UMN score ( = 0.50, = 0.01) ΔFRS ( = 0.52, = 0.008) and serum NFL (lg) ( = 0.55, = 0.004) when estimated only among patients with a disease duration >12 months.
CONCLUSION
We found that CSF sTREM2 is elevated in ALS patients and may be a novel marker, probably reflecting upper motor unit severity and prognosis.
目的
本研究旨在调查脑脊液可溶性触发受体2（sTREM2）是否可能成为肌萎缩侧索硬化症（ALS）疾病监测的潜在标志物。
方法
我们研究了ALS患者脑脊液中sTREM2水平是否发生改变，以及是否与上运动神经元（UMN）负担和疾病进展相关。
结果
ALS患者脑脊液中的sTREM2水平高于对照组（P = 0.002）。脑脊液sTREM2升高与UMN评分（P = 0.38，P = 0.009）、ΔFS（P = 0.30，P = 0.04）和血清神经丝轻链（lg）（P = 0.35，P = 0.015）相关。随着运动带征（MBS）评分增加，脑脊液sTREM2水平升高（P趋势 = 0.014）。此外，仅在病程>12个月的患者中进行评估时，相关性更强（UMN评分（P = 0.50，P = 0.01）、ΔFRS（P = 0.52，P = 0.008）和血清神经丝轻链（lg）（P = 0.55，P = 0.004））。
结论
我们发现ALS患者脑脊液中的sTREM2水平升高，可能是一种新的标志物，可能反映上运动单位的严重程度和预后。
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