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安全使用5α还原酶抑制剂:基层医疗医生需要了解的内容。

Using 5 alpha reductase inhibitors safely: What primary care physicians need to know.

作者信息

Meenrajan Senthil R

机构信息

Department of Medicine, University of Florida, Gainesville, USA.

出版信息

J Family Med Prim Care. 2024 Nov;13(11):4797-4799. doi: 10.4103/jfmpc.jfmpc_575_24. Epub 2024 Nov 18.

DOI:10.4103/jfmpc.jfmpc_575_24
PMID:39722920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668469/
Abstract

5 Alpha Reductase Inhibitor (ARI) is a widely used class of medication; for benign prostatic hypertrophy, androgenetic alopecia and hirsutism. While generally considered safe, ARIs class of medication does have a number of side effects, which can sometimes persist long after discontinuation of the medication. Since this class of medication is generally thought of as being benign, it can be overlooked as a potential cause of new clinical symptoms patients might experience. The purpose of this review is to alert primary care physicians to the more common side effects, so as to always keep adverse drug reaction related to 5ARI as a cause of new symptoms, when evaluating patients, young and old.

摘要

5α还原酶抑制剂(ARI)是一类广泛使用的药物,用于治疗良性前列腺增生、雄激素性脱发和多毛症。虽然通常被认为是安全的,但ARI类药物确实有一些副作用,有时在停药后仍会持续很长时间。由于这类药物通常被认为是良性的,它可能会被忽视,而成为患者可能出现的新临床症状的潜在原因。本综述的目的是提醒初级保健医生注意更常见的副作用,以便在评估所有年龄段的患者时,始终将与5ARI相关的药物不良反应视为新症状的一个原因。

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2
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本文引用的文献

1
5-alpha reductase inhibitors use in prostatic disease and beyond.5-α还原酶抑制剂在前列腺疾病及其他领域的应用。
Transl Androl Urol. 2023 Mar 31;12(3):487-496. doi: 10.21037/tau-22-690. Epub 2023 Mar 6.
2
Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide.5α-还原酶抑制剂与痴呆、抑郁和自杀的关联。
JAMA Netw Open. 2022 Dec 1;5(12):e2248135. doi: 10.1001/jamanetworkopen.2022.48135.
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Post-finasteride syndrome.非那雄胺后综合征
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Post-finasteride syndrome: a surmountable challenge for clinicians.前列腺素后综合征:临床医生可克服的挑战。
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5
Risk of rhabdomyolysis from 5-α reductase inhibitors.5-α还原酶抑制剂导致横纹肌溶解的风险。
Pharmacoepidemiol Drug Saf. 2018 Mar;27(3):351-355. doi: 10.1002/pds.4383. Epub 2018 Jan 25.
6
Prostate cancer prevention with 5-alpha reductase inhibitors: concepts and controversies.5α还原酶抑制剂预防前列腺癌:概念与争议
Curr Opin Urol. 2018 Jan;28(1):42-45. doi: 10.1097/MOU.0000000000000464.
7
The risk of dementia with the use of 5 alpha reductase inhibitors.使用5α还原酶抑制剂后患痴呆症的风险。
J Neurol Sci. 2017 Aug 15;379:109-111. doi: 10.1016/j.jns.2017.05.064. Epub 2017 May 31.
8
Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.5α-还原酶抑制剂对性功能的影响:随机对照试验的荟萃分析与系统评价
J Sex Med. 2016 Sep;13(9):1297-1310. doi: 10.1016/j.jsxm.2016.07.006. Epub 2016 Jul 27.
9
Low Testosterone Level and Risk of Alzheimer's Disease in the Elderly Men: a Systematic Review and Meta-Analysis.老年男性低睾酮水平与阿尔茨海默病风险:一项系统评价和荟萃分析
Mol Neurobiol. 2016 May;53(4):2679-84. doi: 10.1007/s12035-015-9315-y. Epub 2015 Jul 8.
10
Finasteride-induced myalgia and HyperCKemia.非那雄胺引起的肌痛和高肌酸激酶血症。
J Clin Neuromuscul Dis. 2008 Dec;10(2):76-8. doi: 10.1097/CND.0b013e3181873cca.