Gao Xueying, Wang Yuteng, Wang Yikun, Yang Ziyi, Yan Xueqi, Li Shumin, Jiang Yonghui, Li Yimeng, Zhao Shigang, Zhao Han, Chen Zi-Jiang
Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012 Shandong China.
State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, 250012 Shandong China.
Phenomics. 2024 Sep 19;4(5):522-524. doi: 10.1007/s43657-024-00156-y. eCollection 2024 Oct.
Recently, there has been a debate regarding the association between polycystic ovary syndrome (PCOS) and pancreatic cancer (PC). In order to examine the causal relationship between PCOS and PC, we conducted a Mendelian randomization study, which utilized 12 single nucleotide polymorphisms (SNPs) identified from a genome-wide association study (GWAS) meta-analysis that included 10,074 PCOS cases and 103,164 controls of European ancestry as instrumental variables (IVs). The outcome data were obtained from the FinnGen database (including 605 cases and 218,187 controls). We demonstrate that genetically predicted PCOS is not causally associated with PC risk in Europeans (odds ratio = 0.99, 95% confidence interval (CI) = 0.72-1.36, > 0.05). Sensitivity analysis showed horizontal pleiotropy (intercept > 0.05), heterogeneity (Cochran Q > 0.05), and the leave-one-out sensitivity test showed that individual SNP effects had no influence on the results. In conclusion, our study did not provide evidence of a causal link between PCOS and PC.
The online version contains supplementary material available at 10.1007/s43657-024-00156-y.
最近，关于多囊卵巢综合征（PCOS）与胰腺癌（PC）之间的关联存在一场争论。为了研究PCOS与PC之间的因果关系，我们进行了一项孟德尔随机化研究，该研究利用了从一项全基因组关联研究（GWAS）荟萃分析中确定的12个单核苷酸多态性（SNP）作为工具变量（IV），该荟萃分析纳入了10,074例欧洲血统的PCOS病例和103,164例对照。结局数据来自芬兰基因数据库（包括605例病例和218,187例对照）。我们证明，在欧洲人中，基因预测的PCOS与PC风险无因果关联（优势比 = 0.99，95%置信区间（CI）= 0.72 - 1.36，P>0.05）。敏感性分析显示存在水平多效性（截距>0.05）、异质性（ Cochr an Q>0.05），留一法敏感性检验表明单个SNP效应不会影响结果。总之，我们的研究没有提供PCOS与PC之间存在因果联系的证据。
在线版本包含可在10.1007/s43657-024-00156-y获取的补充材料。
