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Anlotinib as a maintenance treatment for advanced soft tissue sarcoma after first-line chemotherapy (ALTER-S006): a multicentre, open-label, single-arm, phase 2 trial.安罗替尼作为一线化疗后晚期软组织肉瘤的维持治疗（ALTER-S006）：一项多中心、开放标签、单臂、2期试验。
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Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma.生物信息学筛选揭示Gli介导的Hedgehog信号通路是去分化脂肪肉瘤免疫浸润不良的相关通路。
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Transcriptome analysis identifies TODL as a novel lncRNA associated with proliferation, differentiation, and tumorigenesis in liposarcoma through FOXM1.转录组分析鉴定 TODL 为一种新型 lncRNA，通过 FOXM1 与脂肪肉瘤的增殖、分化和肿瘤发生相关。
Pharmacol Res. 2022 Nov;185:106462. doi: 10.1016/j.phrs.2022.106462. Epub 2022 Sep 24.
8
Beyond targeting amplified MDM2 and CDK4 in well differentiated and dedifferentiated liposarcomas: From promise and clinical applications towards identification of progression drivers.除了在高分化和去分化脂肪肉瘤中靶向扩增的MDM2和CDK4：从前景与临床应用到鉴定进展驱动因素。
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Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application.综述：精确的肉瘤患者来源原位异种移植（PDOX）小鼠模型有助于确定细胞周期蛋白依赖性激酶抑制剂帕博西尼的新型有效联合疗法：一种临床应用策略。
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10
A phase II trial of regorafenib in patients with advanced Ewing sarcoma and related tumors of soft tissue and bone: SARC024 trial results.一项在晚期尤文肉瘤和相关软组织及骨源性肿瘤患者中应用regorafenib 的 II 期临床试验：SARC024 试验结果。
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靶向脂肪肉瘤：揭示分子途径与治疗机遇

Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities.

作者信息

Liu Hongliang, Wang Xi, Liu Lingyan, Yan Bingsong, Qiu Fabo, Zhou Bin

机构信息

Department of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Department of Oncology, Women and Children's Hospital Affiliated to Qingdao University, Qingdao, China.

出版信息

Front Oncol. 2024 Dec 11;14:1484027. doi: 10.3389/fonc.2024.1484027. eCollection 2024.

DOI:10.3389/fonc.2024.1484027
PMID:39723387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668776/
Abstract

In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field.

摘要

近年来，越来越多的研究利用分子生物学技术揭示不同亚型脂肪肉瘤之间重要的分子异质性。每个亚型都表现出独特的遗传模式和分子途径，这可能成为分子治疗的重要靶点。在本综述中，我们重点关注脂肪肉瘤的分子特征、分子诊断、驱动基因和分子机制。我们还讨论了相关靶向治疗的临床研究进展，旨在为该领域的同行提供参考和重要见解。