Osum Kevin C, Becker Samuel H, Krueger Peter D, Mitchell Jason S, Hong Sung-Wook, Magill Ian R, Jenkins Marc K
Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Department of Biotechnology, Yonsei University, Seoul, South Korea.
Cell Rep. 2025 Jan 28;44(1):115111. doi: 10.1016/j.celrep.2024.115111. Epub 2024 Dec 25.
It is not clear how CD4 memory T cells are formed from a much larger pool of earlier effector cells. We found that transient systemic bacterial infection rapidly generates several antigen-specific T helper (Th)1 and T follicular helper (Tfh) cell populations with different tissue residence behaviors. Although most cells of all varieties had transcriptomes indicative of cell stress and death at the peak of the response, some had already acquired a memory cell signature characterized by expression of genes involved in cell survival. Each Th1 and Tfh cell type was maintained long term by interleukin (IL)-7, except germinal center Tfh cells, which depended on a T cell antigen receptor (TCR) signal. The results indicate that acute infection induces rapid differentiation of Th1 and Tfh cells, a minority of which quickly adopt the gene expression profile of memory cells and survive by signals from the IL-7 receptor or TCR.
目前尚不清楚CD4记忆T细胞是如何从数量多得多的早期效应细胞群体中形成的。我们发现，短暂的全身性细菌感染会迅速产生几个具有不同组织驻留行为的抗原特异性辅助性T（Th）1细胞和滤泡辅助性T（Tfh）细胞群体。尽管在反应高峰期，所有类型的大多数细胞的转录组都表明存在细胞应激和死亡，但有些细胞已经获得了以参与细胞存活的基因表达为特征的记忆细胞特征。除生发中心Tfh细胞依赖于T细胞抗原受体（TCR）信号外，每种Th1和Tfh细胞类型都由白细胞介素（IL）-7长期维持。结果表明，急性感染会诱导Th1和Tfh细胞快速分化，其中少数细胞会迅速采用记忆细胞的基因表达谱，并通过来自IL-7受体或TCR的信号存活下来。
