Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Nat Immunol. 2023 Jun;24(6):903-914. doi: 10.1038/s41590-023-01510-4. Epub 2023 May 8.
Specialized subpopulations of CD4 T cells survey major histocompatibility complex class II-peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4 T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also participate in allergy, autoimmunity, graft rejection and chronic inflammation. Here we provide updates on our understanding of the longevity, functional heterogeneity, differentiation, plasticity, migration and human immunodeficiency virus reservoirs as well as key technological advances that are facilitating the characterization of memory CD4 T cell biology.
专业的 CD4 T 细胞亚群可检测主要组织相容性复合体 II-肽复合物，以控制吞噬体感染、辅助 B 细胞、调节组织稳态和修复或执行免疫调节。记忆 CD4 T 细胞分布于全身，不仅保护组织免受再感染和癌症侵害，而且还参与过敏、自身免疫、移植物排斥和慢性炎症。本文就记忆 CD4 T 细胞的寿命、功能异质性、分化、可塑性、迁移和人类免疫缺陷病毒储存库，以及促进记忆 CD4 T 细胞生物学特性研究的关键技术进展，提供了最新的认识。
