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Inhibiting glioblastoma stem cells by targeting pyruvate carboxylase: a novel therapeutic strategy with both opportunities and challenges.

作者信息

Chen Menghua, Mu Guangjing, Wu Yibo, Bjerkvig Rolf, Wang Hongwei, Wang Donghai, Han Mingzhi

机构信息

Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Health and Function Remodeling, Jinan, China.

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.

出版信息

Neuro Oncol. 2025 Feb 10;27(2):586-588. doi: 10.1093/neuonc/noae249.

DOI:10.1093/neuonc/noae249
PMID:39724389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11812023/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/11812023/cd0cd327fa20/noae249_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/11812023/cd0cd327fa20/noae249_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20fa/11812023/cd0cd327fa20/noae249_fig1.jpg

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本文引用的文献

1
Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.作为丙酮酸羧化酶抑制剂的1,3-二取代咪唑烷-2,4,5-三酮的合成与评价
ACS Med Chem Lett. 2024 Jun 26;15(7):1088-1093. doi: 10.1021/acsmedchemlett.4c00183. eCollection 2024 Jul 11.
2
Metabolic profiling of glioblastoma stem cells reveals pyruvate carboxylase as a critical survival factor and potential therapeutic target.脑胶质瘤干细胞代谢组学分析揭示丙酮酸羧化酶是一个关键的生存因素和潜在的治疗靶点。
Neuro Oncol. 2024 Sep 5;26(9):1572-1586. doi: 10.1093/neuonc/noae106.
3
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.
谷氨酰胺合成酶活性为核苷酸生物合成提供能量，并支持谷氨酰胺受限的胶质母细胞瘤的生长。
Nat Cell Biol. 2015 Dec;17(12):1556-68. doi: 10.1038/ncb3272. Epub 2015 Nov 23.
4
U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells.U-251再探讨：胶质母细胞瘤细胞长期培养的遗传漂变和表型后果
Cancer Med. 2014 Aug;3(4):812-24. doi: 10.1002/cam4.219. Epub 2014 May 8.
5
The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation.3-氯-1,2-丙二醇在大鼠中产生的选择性神经毒性并非能量剥夺的结果。
Toxicology. 2007 Apr 11;232(3):268-76. doi: 10.1016/j.tox.2007.01.013. Epub 2007 Jan 21.
6
Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase.培养的小鼠皮质细胞中的神经元死亡是由甘油醛-3-磷酸脱氢酶（GAPDH）和磷酸丙糖异构酶的抑制所诱导的。
Neurobiol Dis. 1998 Jul;5(1):47-54. doi: 10.1006/nbdi.1998.0177.