Kokurcan Alihan, Sandıkçı Fatih, Yılmaz Muhammet Şahin, Öztürk Ufuk, Doğan Kutsal, Yılmazer Demet, Aydın Fevzi Nuri, Yalçındağ Ali, İmamoğlu Abdurrahim
Department of Urology, Ankara Etlik City Hospital, Ankara, Turkey.
Department of Urology, Health Sciences University, Samsun Training and Research Hospital, Samsun, Turkey.
Int Urol Nephrol. 2025 May;57(5):1441-1449. doi: 10.1007/s11255-024-04338-5. Epub 2024 Dec 26.
To investigate whether tadalafil (TAD) and N-acetyl cysteine (NAC) can prevent cisplatin (CIS)-induced testicular toxicity.
Forty Wistar-Albino rats were divided into five groups: Control group, CIS group, TAD group, NAC group and TAD + NAC group. All groups were compared regarding body and testicular weights, testicular volumes, blood testosterone levels, testicular tissue malondialdehyde (MDA) levels, histopathological features, and testicular Cosentino and Johnsen scores.
There was no significant difference between the groups regarding body weights and Johnsen scores. It was observed that TAD and NAC affected the apoptotic index, and Cosentino scores were lower in these groups than in the control group. This effect was most prominent in the TAD + NAC group. The CIS treatment led to a decrease in serum testosterone levels. While testosterone levels were higher in the TAD Group, no statistically significant difference was found between the groups. Combination therapy and NAC did not affect blood testosterone levels.
Cisplatin has adverse effects on the testicular tissue. The histopathological changes caused by this agent can be prevented by TAD + NAC combination therapy.
研究他达拉非（TAD）和N-乙酰半胱氨酸（NAC）是否能预防顺铂（CIS）诱导的睾丸毒性。
将40只Wistar白化大鼠分为五组：对照组、CIS组、TAD组、NAC组和TAD+NAC组。比较所有组的体重和睾丸重量、睾丸体积、血睾酮水平、睾丸组织丙二醛（MDA）水平、组织病理学特征以及睾丸Cosentino评分和Johnsen评分。
各组间体重和Johnsen评分无显著差异。观察到TAD和NAC影响凋亡指数，且这些组的Cosentino评分低于对照组。这种效应在TAD+NAC组最为显著。CIS治疗导致血清睾酮水平降低。虽然TAD组的睾酮水平较高，但各组间未发现统计学上的显著差异。联合治疗和NAC对血睾酮水平无影响。
顺铂对睾丸组织有不良影响。TAD+NAC联合治疗可预防该药物引起的组织病理学变化。
