Rosenblum Yevgenia, Bogdány Tamás, Nádasy Lili Benedikta, Chen Xinyuan, Kovács Ilona, Gombos Ferenc, Ujma Péter, Bódizs Róbert, Adelhöfer Nico, Simor Péter, Dresler Martin
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behavior, Nijmegen, Netherlands.
Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.
J Sleep Res. 2025 Aug;34(4):e14439. doi: 10.1111/jsr.14439. Epub 2024 Dec 26.
Traditionally categorized as a uniform sleep phase, rapid eye movement sleep exhibits substantial heterogeneity with its phasic and tonic constituents showing marked differences regarding many characteristics. Here, we investigate how tonic and phasic states differ with respect to aperiodic neural activity, a marker of arousal and sleep. Rapid eye movement sleep heterogeneity was assessed using either binary phasic-tonic (n = 97) or continuous (in 60/97 participants) approach. Slopes of the aperiodic power component were measured in the low (2-30 Hz, n = 97) and high (30-48 Hz, n = 60/97) frequency bands with the Irregularly Resampled Auto-Spectral Analysis applied on electroencephalography. Rapid eye movement amplitudes were quantified with the YASA applied on electrooculography (n = 60/97). The binary approach revealed that the phasic state is characterized by steeper low-band slopes with small effect sizes and some topographical heterogeneity over datasets. High-band aperiodic slopes were flatter in the phasic versus tonic state with medium-to-large effect sizes over all areas in both datasets. The continuous approach confirmed these findings. The temporal analysis within rapid eye movement episodes revealed that aperiodic activity preceding or following EM events did not cross-correlate with eye movement amplitudes. This study demonstrates that aperiodic slopes can serve as a reliable marker able to differentiate between phasic and tonic constituents of rapid eye movement sleep and reflect phasic rapid eye movement event intensity. However, rapid eye movement events could not be predicted by preceding aperiodic activity and vice versa, at least not with scalp electroencephalography.
传统上被归类为一种均匀的睡眠阶段，快速眼动睡眠表现出显著的异质性，其相位和张力成分在许多特征方面存在明显差异。在这里，我们研究张力状态和相位状态在非周期性神经活动（一种觉醒和睡眠的标志物）方面是如何不同的。使用二元相位 - 张力（n = 97）或连续（60/97名参与者）方法评估快速眼动睡眠的异质性。使用应用于脑电图的不规则重采样自谱分析在低（2 - 30Hz，n = 97）和高（30 - 48Hz，n = 60/97）频段测量非周期性功率成分的斜率。使用应用于眼电图的YASA（n = 60/97）对快速眼动幅度进行量化。二元方法表明，相位状态的特征是低频频段斜率更陡，效应量小，并且在数据集上存在一些地形异质性。在两个数据集中的所有区域，相位状态与张力状态相比，高频非周期性斜率更平缓，效应量为中到大型。连续方法证实了这些发现。在快速眼动事件内的时间分析表明，眼动事件之前或之后的非周期性活动与眼动幅度没有交叉相关性。这项研究表明，非周期性斜率可以作为一种可靠的标志物，能够区分快速眼动睡眠的相位和张力成分，并反映相位快速眼动事件的强度。然而，快速眼动事件不能由之前的非周期性活动预测，反之亦然，至少使用头皮脑电图是不行的。
