• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

HFM1对于小鼠原始卵泡形成过程中的生殖细胞间桥运输至关重要。

HFM1 is essential for the germ cell intercellular bridge transport in primordial follicle formation in mice.

作者信息

He Yuheng, Wang Huiyuan, Hong Tongtong, Hu Luanqian, Gao Chao, Gao Li, Cui Yugui, Tan Rongrong, Pu Danhua, Wu Jie

机构信息

State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital/Jiangsu Women and Children Health Hospital, Nanjing, 210036, China.

出版信息

Cell Mol Life Sci. 2024 Dec 27;82(1):28. doi: 10.1007/s00018-024-05541-4.

DOI:10.1007/s00018-024-05541-4
PMID:39725823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11671464/
Abstract

The reproductive lifespan of female mammals is determined by the size of the primordial follicle pool, which comprises oocytes enclosed by a layer of flattened pre-granulosa cells. Oocyte differentiation needs acquiring organelles and cytoplasm from sister germ cells in cysts, but the mechanisms regulating this process remain unknown. Previously helicase for meiosis 1 (HFM1) is reported to be related to the development of premature ovarian insufficiency. Here, it is found that HFM1 is involved in oocyte differentiation through organelle enrichment from sister germ cells. Further study indicates that HFM1 is involved in intercellular directional transport through intercellular bridges via the RAC1/ANLN/E-cad signaling pathway, which is indispensable for oocyte differentiation and primordial follicle formation. These findings shed light on the critical role of HFM1 in intercellular bridge transport, which is essential for the establishment of the primordial follicle pool and presenting new horizons for female fertility protection.

摘要

雌性哺乳动物的生殖寿命由原始卵泡池的大小决定，原始卵泡池由一层扁平的前颗粒细胞包裹的卵母细胞组成。卵母细胞分化需要从囊肿中的姐妹生殖细胞获取细胞器和细胞质，但调节这一过程的机制仍不清楚。此前有报道称减数分裂1解旋酶（HFM1）与卵巢早衰的发生有关。在此，研究发现HFM1通过从姐妹生殖细胞富集细胞器参与卵母细胞分化。进一步研究表明，HFM1通过RAC1/ANLN/E-钙黏蛋白信号通路经细胞间桥参与细胞间定向运输，这对卵母细胞分化和原始卵泡形成不可或缺。这些发现揭示了HFM1在细胞间桥运输中的关键作用，这对原始卵泡池的建立至关重要，并为女性生育保护提供了新的视野。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/195039a2d45a/18_2024_5541_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/43fff961a1a4/18_2024_5541_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/91e27a699155/18_2024_5541_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/e506bc67610f/18_2024_5541_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/13af3d4b4634/18_2024_5541_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/a05799183a14/18_2024_5541_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/d3be73186993/18_2024_5541_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/9b34da1cb7c2/18_2024_5541_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/195039a2d45a/18_2024_5541_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/43fff961a1a4/18_2024_5541_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/91e27a699155/18_2024_5541_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/e506bc67610f/18_2024_5541_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/13af3d4b4634/18_2024_5541_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/a05799183a14/18_2024_5541_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/d3be73186993/18_2024_5541_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/9b34da1cb7c2/18_2024_5541_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230e/11671464/195039a2d45a/18_2024_5541_Fig8_HTML.jpg

相似文献

1
HFM1 is essential for the germ cell intercellular bridge transport in primordial follicle formation in mice.HFM1对于小鼠原始卵泡形成过程中的生殖细胞间桥运输至关重要。
Cell Mol Life Sci. 2024 Dec 27;82(1):28. doi: 10.1007/s00018-024-05541-4.
2
Mechanisms controlling germline cyst breakdown and primordial follicle formation.控制生殖系囊肿破裂和原始卵泡形成的机制。
Cell Mol Life Sci. 2017 Jul;74(14):2547-2566. doi: 10.1007/s00018-017-2480-6. Epub 2017 Feb 14.
3
The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice.HFM1 在调节 FUS 泛素化和定位以促进小鼠卵母细胞减数分裂前期 I 进展中的关键作用。
Biol Res. 2024 May 31;57(1):36. doi: 10.1186/s40659-024-00518-w.
4
Hfm1 participates in Golgi-associated spindle assembly and division in mouse oocyte meiosis.Hfm1 参与小鼠卵母细胞减数分裂中与高尔基体相关的纺锤体组装和分裂。
Cell Death Dis. 2020 Jun 30;11(6):490. doi: 10.1038/s41419-020-2697-4.
5
HDAC6 regulates primordial follicle activation through mTOR signaling pathway.HDAC6 通过 mTOR 信号通路调控原始卵泡的激活。
Cell Death Dis. 2021 May 29;12(6):559. doi: 10.1038/s41419-021-03842-1.
6
Arrest at the diplotene stage of meiotic prophase I is delayed by progesterone but is not required for primordial follicle formation in mice.减数分裂前期I双线期的停滞会被孕酮延迟，但小鼠原始卵泡形成并不需要这种停滞。
Reprod Biol Endocrinol. 2016 Dec 5;14(1):82. doi: 10.1186/s12958-016-0218-1.
7
Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.单细胞 RNA 测序揭示了小鼠原始卵泡形成过程中生殖细胞高度协调的转录程序。
Aging Cell. 2021 Jul;20(7):e13424. doi: 10.1111/acel.13424. Epub 2021 Jun 26.
8
Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice.在小鼠中，Rac1通过促进STAT3指导的锯齿状蛋白1、生长分化因子9和骨形态发生蛋白15的转录来调节原始卵泡的形成。
Sci Rep. 2016 Apr 6;6:23972. doi: 10.1038/srep23972.
9
The infant and pubertal human ovary: Balbiani's body-associated VASA expression, immunohistochemical detection of apoptosis-related BCL2 and BAX proteins, and DNA fragmentation.人类婴儿和青春期卵巢：巴尔比尼小体相关 VASA 表达、凋亡相关 BCL2 和 BAX 蛋白的免疫组织化学检测以及 DNA 片段化。
Hum Reprod. 2013 Mar;28(3):698-706. doi: 10.1093/humrep/des453. Epub 2013 Jan 12.
10
BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2.在人类胎儿卵巢体细胞中，骨形态发生蛋白（BMP）信号传导以基因特异性方式受到GREM1和GREM2的调节。
Mol Hum Reprod. 2016 Sep;22(9):622-33. doi: 10.1093/molehr/gaw044. Epub 2016 Jul 6.

引用本文的文献

1
Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K/Akt signaling pathway.槲皮素通过靶向PI3K/Akt信号通路促进脊髓损伤后的血管生成并保护血脊髓屏障结构。
J Transl Med. 2025 Aug 25;23(1):958. doi: 10.1186/s12967-025-06973-7.

本文引用的文献

1
The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice.HFM1 在调节 FUS 泛素化和定位以促进小鼠卵母细胞减数分裂前期 I 进展中的关键作用。
Biol Res. 2024 May 31;57(1):36. doi: 10.1186/s40659-024-00518-w.
2
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis.胞吐作用介导的 ALIX 和 ESCRT-III 在细胞分裂期间向细胞间桥的运输。
Cell Mol Life Sci. 2023 Jul 31;80(8):235. doi: 10.1007/s00018-023-04864-y.
3
Making a good egg: human oocyte health, aging, and in vitro development.
制造优质卵子：人类卵母细胞健康、衰老和体外发育。
Physiol Rev. 2023 Oct 1;103(4):2623-2677. doi: 10.1152/physrev.00032.2022. Epub 2023 May 12.
4
Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice.分支性生殖细胞囊和雌性特异性囊泡碎裂有助于小鼠卵母细胞的决定。
Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2219683120. doi: 10.1073/pnas.2219683120. Epub 2023 May 8.
5
Conservation of oocyte development in germline cysts from to mouse.维持生殖泡中卵母细胞的发育 至 小鼠。
Elife. 2022 Nov 29;11:e83230. doi: 10.7554/eLife.83230.
6
The impact of oocyte death on mouse primordial follicle formation and ovarian reserve.卵母细胞死亡对小鼠原始卵泡形成和卵巢储备的影响。
Reprod Med Biol. 2022 Nov 1;21(1):e12489. doi: 10.1002/rmb2.12489. eCollection 2022 Jan-Dec.
7
Obesity and Adipose Tissue Dysfunction: From Pediatrics to Adults.肥胖与脂肪组织功能障碍：从儿科到成人。
Genes (Basel). 2022 Oct 15;13(10):1866. doi: 10.3390/genes13101866.
8
p120 regulates E-cadherin expression in nasal epithelial cells in chronic rhinosinusitis.p120 在慢性鼻-鼻窦炎的鼻上皮细胞中调节 E-钙黏蛋白的表达。
Rhinology. 2022 Aug 1;60(4):270-281. doi: 10.4193/Rhin21.276.
9
Mouse oocytes develop in cysts with the help of nurse cells.小鼠卵母细胞在滋养细胞的帮助下在囊泡中发育。
Cell. 2022 Jul 7;185(14):2576-2590.e12. doi: 10.1016/j.cell.2022.05.001. Epub 2022 May 26.
10
Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation.单细胞 RNA 测序揭示了小鼠原始卵泡形成过程中生殖细胞高度协调的转录程序。
Aging Cell. 2021 Jul;20(7):e13424. doi: 10.1111/acel.13424. Epub 2021 Jun 26.