Zhang Ming, Qu Jianli, Guo Weiwei, Liu Yi, Zhang Wei
Department of Pathology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Department of Hematology, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, 264003, Shandong, China.
Diagn Pathol. 2024 Dec 26;19(1):165. doi: 10.1186/s13000-024-01593-z.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (EMZL) is an indolent B-cell lymphoma that can involve various anatomic sites. EMZL is derived from post-germinal center marginal zone B cells and typically lacks bcl-6 expression. Herein, we report two post-treatment cases of EMZL where unexpected bcl-6 protein expression was observed in specimens obtained following recurrence or progression. This contrasts with the primary specimens, which were negative for the bcl-6. Additionally, we confirm that the altered bcl6 expression observed in relapsed EMZL cases is independent of BCL6 gene rearrangement, as demonstrated by fluorescence in situ hybridization analysis. Relevant literature was reviewed and summarized to enhance the understanding of this phenomenon, particularly for pathologists.
黏膜相关淋巴组织结外边缘区淋巴瘤（EMZL）是一种惰性B细胞淋巴瘤，可累及多个解剖部位。EMZL起源于生发中心后边缘区B细胞，通常缺乏bcl-6表达。在此，我们报告2例EMZL治疗后病例，在复发或进展后获取的标本中观察到意外的bcl-6蛋白表达。这与原发性标本形成对比，原发性标本的bcl-6为阴性。此外，我们证实复发EMZL病例中观察到的bcl6表达改变与BCL6基因重排无关，荧光原位杂交分析已证明这一点。我们查阅并总结了相关文献，以增进对这一现象的理解，特别是对病理学家而言。
