Alshaibani Askar K, Alanazi Reem R, Aleid Bedour Akif, Alosaimi Saad M
Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.
Department of Ophthalmology, College of Medicine, King Fahad Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
J Med Case Rep. 2024 Dec 26;18(1):640. doi: 10.1186/s13256-024-04996-0.
Klinefelter syndrome is considered one of the most common sex chromosome disorders affecting males. The presence of an extra X chromosome can alter the tendency to develop various cancers, including lymphomas. Lacrimal gland lymphoma is a disease of the elderly, with a median age of presentation of 70 years.
In this article, we report a case of a 35-year-old Arabian Saudi male with a known case of Klinefelter syndrome who presented to oculoplastic clinic complaining of progressively growing superior-temporal mass in the left eye. After evaluation and imaging, an incisional biopsy from the lacrimal gland mass was obtained and histopathological evaluation showed atypical lymphoproliferative infiltrate consistent with extranodal marginal zone lymphoma of mucosa associated lymphoid tissue. The mainstay treatment was external beam radiotherapy, which showed significant improvement in the case.
This is considered the first reported case of lacrimal gland lymphoma in young patient with Klinefelter syndrome, which increases the association between Klinefelter syndrome and lymphomas.
克氏综合征被认为是影响男性的最常见性染色体疾病之一。额外的X染色体的存在会改变患各种癌症的倾向，包括淋巴瘤。泪腺淋巴瘤是一种老年疾病，中位发病年龄为70岁。
在本文中，我们报告了一例35岁的沙特阿拉伯男性，他患有克氏综合征，到眼科整形诊所就诊，主诉左眼颞上肿块逐渐增大。经过评估和影像学检查，从泪腺肿块处进行了切开活检，组织病理学评估显示非典型淋巴增殖性浸润，符合黏膜相关淋巴组织结外边缘区淋巴瘤。主要治疗方法是外照射放疗，该病例显示出显著改善。
这被认为是首例关于克氏综合征年轻患者泪腺淋巴瘤的报道病例，这增加了克氏综合征与淋巴瘤之间的关联。
