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伪装成便秘的神经母细胞瘤:通过儿科腹部即时超声检查减少诊断错误

Neuroblastoma Masquerading as Constipation: Reducing Diagnostic Error With the Pediatric Abdominal Point-of-Care Ultrasound Survey.

作者信息

Schonert Jonathan, Denne Nick, Minardi Joe

机构信息

Department of Emergency Medicine, St. Luke's Hospital, Chesterfield, USA.

Department of Emergency Medicine, West Virginia University School of Medicine, Morgantown, USA.

出版信息

Cureus. 2024 Nov 25;16(11):e74427. doi: 10.7759/cureus.74427. eCollection 2024 Nov.

DOI:10.7759/cureus.74427
PMID:39726472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11670146/
Abstract

Abdominal pain is a common pediatric complaint in the emergency department and other clinical settings. While most causes are benign, dangerous and time-sensitive conditions may be present. Point-of-care ultrasound (POCUS) is a diagnostic modality that can help more thoroughly explore the differential diagnosis at a relatively low cost, without exposure to ionizing radiation, and in a timely manner.  This report presents the case of a three-year-old male with three weeks of abdominal pain, constipation, poor appetite, and weight loss that were evaluated multiple times for presumed constipation. POCUS at a rural critical access emergency department revealed an echogenic mass encasing the aorta and causing hydronephrosis, later confirmed as neuroblastoma on CT and biopsy. Comprehensive oncologic care was initiated at a tertiary care center. Neuroblastoma, one of the more common forms of childhood cancer, particularly in the first year of life, often presents with non-specific symptoms that can delay diagnosis. This case report highlights the role of POCUS, and the authors introduce the incorporation of the PAPS exam (pediatric abdominal POCUS survey) in the evaluation of vague pediatric abdominal pain to improve diagnostic accuracy and reduce errors.

摘要

腹痛是急诊科和其他临床环境中常见的儿科主诉。虽然大多数病因是良性的,但可能存在危险且具有时间敏感性的病症。床旁超声(POCUS)是一种诊断方式,它能够以相对较低的成本,在不接触电离辐射的情况下及时帮助更全面地探究鉴别诊断。本报告介绍了一名三岁男性患儿的病例,该患儿有三周的腹痛、便秘、食欲不振和体重减轻症状,因疑似便秘接受了多次评估。一家农村急救急诊科的床旁超声检查发现一个回声团块包裹着主动脉并导致肾积水,随后通过CT和活检确诊为神经母细胞瘤。在一家三级医疗中心启动了全面的肿瘤护理。神经母细胞瘤是儿童癌症较常见的形式之一,尤其是在生命的第一年,通常表现为非特异性症状,可能会延迟诊断。本病例报告强调了床旁超声的作用,作者介绍了将儿科腹部床旁超声检查(PAPS检查)纳入对模糊不清的儿科腹痛的评估中,以提高诊断准确性并减少误诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/6b0d30f41f79/cureus-0016-00000074427-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/c418affff20d/cureus-0016-00000074427-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/2e4dd084839f/cureus-0016-00000074427-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/a0f9d0508ec1/cureus-0016-00000074427-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/9d26be432522/cureus-0016-00000074427-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/6b0d30f41f79/cureus-0016-00000074427-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/c418affff20d/cureus-0016-00000074427-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/2e4dd084839f/cureus-0016-00000074427-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/a0f9d0508ec1/cureus-0016-00000074427-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/9d26be432522/cureus-0016-00000074427-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/231c/11670146/6b0d30f41f79/cureus-0016-00000074427-i05.jpg

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本文引用的文献

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Point-of-Care Ultrasound of a Pediatric Gastric Trichobezoar: A Case Report.儿科胃毛蚴石的床旁超声:病例报告。
Pediatr Emerg Care. 2023 Nov 1;39(11):892-894. doi: 10.1097/PEC.0000000000003062. Epub 2023 Oct 8.
2
Updates in pediatric ultrasound.儿科超声的新进展。
Curr Opin Pediatr. 2023 Jun 1;35(3):324-330. doi: 10.1097/MOP.0000000000001244. Epub 2023 Mar 28.
3
Point-of-Care Ultrasound May Reduce Misdiagnosis of Pediatric Intussusception.床旁超声检查可能减少小儿肠套叠的误诊。
Front Pediatr. 2021 Feb 4;9:601492. doi: 10.3389/fped.2021.601492. eCollection 2021.
4
Diagnostic Accuracy of Point-Of-Care Ultrasound for Intussusception Performed by Pediatric Emergency Medicine Physicians.儿科急诊医师床边超声检查对肠套叠的诊断准确性。
J Emerg Med. 2021 May;60(5):626-632. doi: 10.1016/j.jemermed.2020.11.030. Epub 2021 Jan 19.
5
Mass screening for neuroblastoma in infants.婴儿神经母细胞瘤的群体筛查。
Discov Med. 2020 Sep-Oct;30(160):63-70.
6
Accuracy of point-of-care ultrasound by pediatric emergency physicians for testicular torsion.儿科急诊医生进行床边超声检查诊断睾丸扭转的准确性。
J Pediatr Urol. 2019 Dec;15(6):608.e1-608.e6. doi: 10.1016/j.jpurol.2019.07.003. Epub 2019 Jul 12.
7
Point-of-Care Ultrasound Identification of a Psoas Abscess in a Child Presenting With Hip Pain.床旁超声对一名以髋关节疼痛就诊儿童的腰大肌脓肿的诊断
Pediatr Emerg Care. 2017 Jun;33(6):437-439. doi: 10.1097/PEC.0000000000001159.
8
Diagnostic Accuracy of History, Physical Examination, Laboratory Tests, and Point-of-care Ultrasound for Pediatric Acute Appendicitis in the Emergency Department: A Systematic Review and Meta-analysis.急诊科小儿急性阑尾炎病史、体格检查、实验室检查及床旁超声的诊断准确性:一项系统评价和荟萃分析
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Pediatric emergency medicine point-of-care ultrasound: summary of the evidence.儿科急诊医学床旁超声:证据总结
Crit Ultrasound J. 2016 Dec;8(1):16. doi: 10.1186/s13089-016-0049-5. Epub 2016 Nov 3.
10
Avoiding misdiagnosing neuroblastoma as Wilms tumor.避免将神经母细胞瘤误诊为肾母细胞瘤。
J Pediatr Surg. 2008 Jun;43(6):1159-63. doi: 10.1016/j.jpedsurg.2008.02.047.