Meng Sibo, Yang Guanghui, Yu Enhao, Li Jiaxin
Qilu Hospital, Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China.
Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Front Immunol. 2024 Dec 12;15:1477828. doi: 10.3389/fimmu.2024.1477828. eCollection 2024.
This research endeavors to delve into the research hotspots and trends concerning RNA methylation and tumor immune cells through the application of bibliometric analysis and visualization techniques.
A comprehensive search in WoSCC (2014-2023) for RNA methylation and tumor immune cell articles/reviews was conducted. Bibliometric analysis and visualization employed CiteSpace, Bibliometric, and VOSviewer tools.
A total of 3295 articles were included in the analysis, with a continuously increasing number of publications linking RNA methylation to tumoral immune cells. Chinese authors and research institutions have demonstrated a sustained growth trend in both the number of publications and author influence. SUN YAT SEN UNIVERSITY, a Chinese institution, has published the highest number of articles in this field, while also demonstrating extensive international and inter-institutional collaborations. Meanwhile, HARVARD UNIVERSITY has also achieved impressive results. For instance, Frontiers in Immunology has published the largest number of articles in this category. Nature Communications has published articles that are most influential in this field, playing a pivotal role in disseminating research findings. The sustained vitality of this field is attributed to its solid research foundation, including the groundbreaking work published by Professor Chiappinelli KB in Cell and the widely cited paper by Professor Han DL in Nature. Analysis of research trend topics reveals that m5C, immunotherapy, and the immune microenvironment are current research focuses.
Future investigative efforts at the juncture of RNA methylation and tumor immune cells are anticipated to concentrate on domains including m5C, n7-methylguanosine, cuproptosis, prognosis assessment, immunotherapeutic strategies, and the tumor microenvironment.
本研究旨在通过文献计量分析和可视化技术，深入探讨RNA甲基化与肿瘤免疫细胞的研究热点和趋势。
在WoSCC（2014 - 2023年）中全面检索关于RNA甲基化和肿瘤免疫细胞的文章/综述。文献计量分析和可视化采用CiteSpace、Bibliometric和VOSviewer工具。
分析共纳入3295篇文章，将RNA甲基化与肿瘤免疫细胞联系起来的出版物数量持续增加。中国作者和研究机构在出版物数量和作者影响力方面均呈现持续增长趋势。中国的中山大学在该领域发表的文章数量最多，同时也展示了广泛的国际和机构间合作。与此同时，哈佛大学也取得了令人瞩目的成果。例如，《免疫学前沿》发表此类文章的数量最多。《自然通讯》发表的文章在该领域最具影响力，在传播研究结果方面发挥了关键作用。该领域的持续活力归因于其坚实的研究基础，包括Chiappinelli KB教授在《细胞》杂志上发表的开创性工作以及Han DL教授在《自然》杂志上被广泛引用的论文。对研究趋势主题的分析表明，m5C、免疫疗法和免疫微环境是当前的研究重点。
预计未来在RNA甲基化与肿瘤免疫细胞交叉领域的研究工作将集中在包括m5C、N7 - 甲基鸟苷、铜死亡、预后评估、免疫治疗策略和肿瘤微环境等领域。
