Cong Yuyang, Abulimiti Muyasha, Matsumoto Yoshitaka, Jin Jing
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Department of Radiation Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Front Oncol. 2024 Dec 12;14:1507157. doi: 10.3389/fonc.2024.1507157. eCollection 2024.
This study aimed to describe the trends, current hotspots, and future directions in boron neutron capture therapy (BNCT) through a bibliometric analysis.
Articles related to BNCT published before 2023-12-31 were retrieved from the Web of Science Core Collection database. VOSviewer, R, and CiteSpace were used for bibliometric analysis and visualization.
A total of 3347 related publications from 1975 to 2023 were retrieved. Since a burst of published documents in 1992, the past three decades have witnessed continuous investigations into BNCT-related studies. Japan was the most productive country (794, 23.72%), followed by the USA (792, 23.66%), while the latter had the most citations. Kyoto University was the most influential institution. Ono K was the most prolific author, and was the most popular journal. Ono K was the author that had the most total citations, followed by Barth RF. "Carborane", "boronophenylalanine", "glioblastoma", "sodium borocaptate", "cancer" and "drug delivery" were the most frequent keywords. The article "Dendrimers and dendritic polymers in drug delivery" had the most citations, whereas "Boron delivery agents for neutron capture therapy of cancer" had the highest outbreak value.
Over the past three decades, research on BNCT has expanded significantly, with the development of novel boron carriers with improved medicinal characteristics being the most extensively investigated area. Future research will likely focus on the validation and modification of current BNCT treatment modalities using conventional boron agents in brain tumors, accelerator-based neutron sources and the application of BNCT in more clinical scenarios.
本研究旨在通过文献计量分析描述硼中子俘获疗法（BNCT）的发展趋势、当前热点和未来方向。
从Web of Science核心合集数据库中检索2023年12月31日前发表的与BNCT相关的文章。使用VOSviewer、R和CiteSpace进行文献计量分析和可视化。
共检索到1975年至2023年的3347篇相关出版物。自1992年发表文献数量激增以来，过去三十年对BNCT相关研究的调查不断。日本是发文量最多的国家（794篇，23.72%），其次是美国（792篇，23.66%），而美国的被引次数最多。京都大学是最具影响力的机构。小野健是发文量最多的作者， 是最受欢迎的期刊。小野健是总被引次数最多的作者，其次是巴特·R·F。“碳硼烷”、“硼苯丙氨酸”、“胶质母细胞瘤”、“硼酸钠铍”、“癌症”和“药物递送”是最常见的关键词。文章《树枝状大分子和树枝状聚合物在药物递送中的应用》被引次数最多，而《用于癌症中子俘获治疗的硼递送剂》的爆发值最高。
在过去三十年中，BNCT的研究显著扩展，开发具有改善药用特性的新型硼载体是研究最广泛的领域。未来的研究可能会集中在使用传统硼剂对当前BNCT治疗模式在脑肿瘤中的验证和改进、基于加速器的中子源以及BNCT在更多临床场景中的应用。
