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大花红景天苷B通过COX-2/PGE途径抑制子宫内膜异位症中的上皮-间质转化。

Macranthoidin B restrains the epithelial-mesenchymal transition through COX-2/PGE pathway in endometriosis.

作者信息

Ding Yi, Yang Xiaoqian, Wei Qinghua, Bi Xuanming, Zhang Yuxin, Ma Yuxia, Yang Meisen, Xu Xiaoyu, Li Cong, Wang Qin, Chen Yi

机构信息

School of Chinese Materia Medica, Chongqing University of Chinese Medicine, Chongqing, China.

College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, China.

出版信息

Front Pharmacol. 2024 Dec 12;15:1492098. doi: 10.3389/fphar.2024.1492098. eCollection 2024.

DOI:10.3389/fphar.2024.1492098
PMID:39726776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11669684/
Abstract

INTRODUCTION

Macranthoidin B is one of the primary and unique triterpenoid saponin metabolites from Hand. -Mazz, which is used to treat endometriosis (EMS) in traditional Chinese medicine. However, the effect of macranthoidin B remains unknown in EMS. This study aimed to elucidate the effect and mechanism of macranthoidin B in EMS.

METHODS

Using rat autograft EMS model, the volume of ectopic endothelium, the histopathology, serum E and PROG were evaluated after macranthoidin B's treatment. In primary endometriotic stromal and HEC1-B cells, the invasion and metastasis were assessed by scratch wound and Transwell tests. The epithelial-mesenchymal transition and COX-2/PGE pathway were examined and . Macranthoidin B were combined with LPS or celecoxib.

RESULTS

In a rat autograft EMS model, macranthoidin B suppressed ectopic lesion volume, improved histopathological morphology, and regulated serum estradiol (E2) and progesterone (PROG) levels. Additionally, macranthoidin B inhibited invasion and metastasis of primary endometriotic stromal cells and HEC1-B cells. Mechanistically, macranthoidin B suppressed COX-2/PGE pathway and epithelial-mesenchymal transition both and . LPS, the COX-2/PGE2 pathway activator, showed the promotion of epithelial-mesenchymal transition, invasion and metastasis. Macranthoidin B exhibited the antagonistic effects against LPS. Celecoxib, the COX-2/PGE2 pathway inhibitor, restrained the epithelial-mesenchymal transition, invasion and metastasis. This effect of celecoxib was enhanced by macranthoidin B.

DISCUSSION

Macranthoidin B prevents epithelial-mesenchymal transition through COX-2/PGE2 pathway in EMS. It will facilitate the macranthoidin B's development and broaden its potential application.

摘要

引言

大花红景天苷B是红景天属植物中主要且独特的三萜皂苷代谢产物之一，在传统中医中用于治疗子宫内膜异位症（EMS）。然而，大花红景天苷B在EMS中的作用尚不清楚。本研究旨在阐明大花红景天苷B在EMS中的作用及机制。

方法

使用大鼠自体移植EMS模型，在大花红景天苷B治疗后评估异位内膜体积、组织病理学、血清E和PROG。在原代子宫内膜间质细胞和HEC1-B细胞中，通过划痕伤口和Transwell试验评估侵袭和转移。检测上皮-间质转化和COX-2/PGE通路。大花红景天苷B与LPS或塞来昔布联合使用。

结果

在大鼠自体移植EMS模型中，大花红景天苷B抑制异位病变体积，改善组织病理学形态，并调节血清雌二醇（E2）和孕酮（PROG）水平。此外，大花红景天苷B抑制原代子宫内膜间质细胞和HEC1-B细胞的侵袭和转移。机制上，大花红景天苷B在体内和体外均抑制COX-2/PGE通路和上皮-间质转化。LPS，COX-2/PGE2通路激活剂，显示促进上皮-间质转化、侵袭和转移。大花红景天苷B对LPS具有拮抗作用。塞来昔布，COX-2/PGE2通路抑制剂，抑制上皮-间质转化、侵袭和转移。大花红景天苷B增强了塞来昔布的这种作用。

讨论

大花红景天苷B通过COX-2/PGE2通路在EMS中阻止上皮-间质转化。这将促进大花红景天苷B的开发并拓宽其潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/20389038cb61/fphar-15-1492098-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/1571f00718ed/fphar-15-1492098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/cb82e571b5cc/fphar-15-1492098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/690cdf31ee8f/fphar-15-1492098-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/b349a9e285c3/fphar-15-1492098-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/8f2ce1c5f5ba/fphar-15-1492098-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/20389038cb61/fphar-15-1492098-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/1571f00718ed/fphar-15-1492098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/cb82e571b5cc/fphar-15-1492098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/690cdf31ee8f/fphar-15-1492098-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/b349a9e285c3/fphar-15-1492098-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/8f2ce1c5f5ba/fphar-15-1492098-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb49/11669684/20389038cb61/fphar-15-1492098-g006.jpg

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