Wang Ziyi, Li Zehui, Sun Xiangyu, Men Wanfu, Xu Yan
Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Pharmacol. 2024 Dec 11;15:1463538. doi: 10.3389/fphar.2024.1463538. eCollection 2024.
Metastasis is the leading cause of cancer-related death in cancer patients. Tumor cells primarily spread through the hematogenous and lymphatic system. The underlying mechanisms of hematogenous metastasis have been well described over the past few decades. However, the understanding of the molecular mechanisms involved in lymphatic metastasis is still at an early stage. Tumor microenvironment (TME), primarily consisting of T cells, B cells, tumor-associated macrophages, neutrophils, and cancer-associated fibroblasts, has been implicated in the development of lymphatic metastasis. Recent studies have been reported that the dynamic and complex interplay between these cellular components of TME has great effects on lymphatic metastasis. Here, we discussed the paradoxical roles of these cellular component within the TME during lymphatic metastasis, as well as potential therapeutic opportunities to re-educate these cells within the TME to have anti-tumorigenic effects.
转移是癌症患者癌症相关死亡的主要原因。肿瘤细胞主要通过血液和淋巴系统扩散。在过去几十年中，对血行转移的潜在机制已有充分描述。然而，对淋巴转移所涉及分子机制的理解仍处于早期阶段。肿瘤微环境（TME）主要由T细胞、B细胞、肿瘤相关巨噬细胞、中性粒细胞和癌症相关成纤维细胞组成，已被认为与淋巴转移的发生有关。最近的研究报道，TME中这些细胞成分之间动态而复杂的相互作用对淋巴转移有很大影响。在此，我们讨论了TME中这些细胞成分在淋巴转移过程中的矛盾作用，以及重新引导TME中的这些细胞产生抗肿瘤作用的潜在治疗机会。
