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聚（2-氨基酚）/金纳米颗粒在808纳米光协同作用下对黑色素瘤癌细胞增强阿霉素治疗效果的光敏活性

Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light.

作者信息

Sattarahmady Naghmeh, Kayani Zahra, Heli Hossein, Faghani-Eskandarkolaei Parsa, Haghighi Hanieh

机构信息

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

J Biomed Phys Eng. 2024 Dec 1;14(6):547-560. doi: 10.31661/jbpe.v0i0.2312-1693. eCollection 2024 Dec.

DOI:10.31661/jbpe.v0i0.2312-1693
PMID:39726887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668927/
Abstract

BACKGROUND

Photothermal therapy (PTT) is one of the effective and non-invasive strategies which hold great promise for improving the treatment of cancer cells. PTT is based on activating a photosensitizer by infrared light irradiation and producing heat and reactive species and apoptosis in the tumor area.

OBJECTIVE

The aim of this study was to investigate the effect of photothermal/chemotherapy on melanoma cancer cells using poly (2-amino phenol)/gold (P2AO/AuNPs) and doxorubicin (DOX).

MATERIAL AND METHODS

In this experimental study, nanoparticles of P2AO/AuNPs were synthesized, and their mixture with DOX was applied as a photosensitizer for photothermal/chemotherapy of a C540 (B16-F10) melanoma cell line.

RESULTS

P2AO/AuNPs generated heat and cytotoxic responsive oxygen species (ROS) upon 808-nm light irradiation with simultaneous intensifying DOX therapeutic effect under domination of synergism effects between light irradiation, P2AO/AuNPs, and doxorubicin. Cell treatment with both P2AO/AuNPs and DOX resulted in a considerable increase in necroptotic cells to 61% with a significant decrease in the living cells (39%).

CONCLUSION

P2AO/AuNPs provided a platform for light absorption and intensifying DOX therapeutic effect. This study approved the applicability of a new photothermal/chemotherapy by domination of synergistic effects attained by combination of laser light, P2AO, AuNPs, and DOX.

摘要

背景

光热疗法（PTT）是一种有效且无创的策略，在改善癌细胞治疗方面具有巨大潜力。PTT基于通过红外光照射激活光敏剂，并在肿瘤区域产生热量、活性物质和诱导细胞凋亡。

目的

本研究旨在探讨聚（2-氨基酚）/金（P2AO/AuNPs）和阿霉素（DOX）用于光热/化疗对黑色素瘤癌细胞的影响。

材料与方法

在本实验研究中，合成了P2AO/AuNPs纳米颗粒，并将其与DOX的混合物用作C540（B16-F10）黑色素瘤细胞系光热/化疗的光敏剂。

结果

在808nm光照射下，P2AO/AuNPs产生热量和细胞毒性反应性氧物种（ROS），同时在光照射、P2AO/AuNPs和阿霉素之间的协同作用主导下增强DOX的治疗效果。用P2AO/AuNPs和DOX处理细胞导致坏死性细胞显著增加至61%，活细胞显著减少（39%）。

结论

P2AO/AuNPs为光吸收和增强DOX治疗效果提供了一个平台。本研究通过激光、P2AO、AuNPs和DOX组合产生的协同作用，验证了一种新型光热/化疗的适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/d66ae834289f/JBPE-14-547-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/aca30ead341d/JBPE-14-547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/241c3f0d77e0/JBPE-14-547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/f5d56fc528da/JBPE-14-547-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/0949b2203b36/JBPE-14-547-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/207a559c26fc/JBPE-14-547-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/d66ae834289f/JBPE-14-547-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/aca30ead341d/JBPE-14-547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/241c3f0d77e0/JBPE-14-547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/f5d56fc528da/JBPE-14-547-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/0949b2203b36/JBPE-14-547-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/207a559c26fc/JBPE-14-547-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d1e/11668927/d66ae834289f/JBPE-14-547-g006.jpg

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Redox-active polyphenol nanoparticles deprive endogenous glutathione of electrons for ROS generation and tumor chemodynamic therapy.氧化还原活性多酚纳米颗粒剥夺内源性谷胱甘肽的电子以产生 ROS 并进行肿瘤化学动力学治疗。
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Bridging Gaps in Peripheral Nerves: From Current Strategies to Future Perspectives in Conduit Design.
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Connecting the dots: Melanoma cell of origin, tumor cell plasticity, trans-differentiation, and drug resistance.串联各点：黑素瘤细胞起源、肿瘤细胞可塑性、转分化和耐药性。
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Epigenetic modulation and prostate cancer: Paving the way for NK cell anti-tumor immunity.表观遗传调控与前列腺癌：为 NK 细胞抗肿瘤免疫铺平道路。
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