Kim Hyejin, Nguyen Van Phuc, Manivasagan Panchanathan, Jung Min Jung, Kim Sung Won, Oh Junghwan, Kang Hyun Wook
Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering, Pukyong National University, Busan, South Korea.
Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology (BK 21 Plus), Pukyong National University, Busan, South Korea.
Oncotarget. 2017 Dec 9;8(69):113719-113733. doi: 10.18632/oncotarget.23092. eCollection 2017 Dec 26.
The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for dual-chemotherapy and photothermal treatment (PTT) on eye tumors and . Marine-derived Fu was used as a capping agent to achieve high photostability for AuNPs, and Dox as a FDA-approved anti-cancer drug was added to induce chemotherapy. The synthesized Dox-Fu@AuNPs exhibited high cytotoxicity on the tumor cells and strong light absorption for temperature increase . After intratumoral injection of Dox-Fu@AuNPs in the rabbit eye tumors, PTT-assisted Dox-Fu@AuNPs entailed the complete removal of the eye tumors without recurrence for 14 days after the treatment. Photoacoustic image contrast from the tumor regions was enhanced due to selective light absorption by the administered Dox-Fu@AuNPs. Therefore, the proposed Dox-Fu@AuNPs can be a potential nano-theranostic material for treating and diagnosing the eye tumors.
当前研究表明，负载阿霉素（Dox）的岩藻聚糖（Fu）包覆的金纳米颗粒（AuNPs）在眼部肿瘤的双重化疗和光热治疗（PTT）方面具有可行的生物医学应用。源自海洋的Fu用作封端剂以实现AuNPs的高光稳定性，并添加FDA批准的抗癌药物Dox以诱导化疗。合成的Dox-Fu@AuNPs对肿瘤细胞表现出高细胞毒性以及对温度升高的强光吸收。在兔眼肿瘤内注射Dox-Fu@AuNPs后，PTT辅助的Dox-Fu@AuNPs在治疗后14天实现了眼部肿瘤的完全清除且无复发。由于给药的Dox-Fu@AuNPs的选择性光吸收，肿瘤区域的光声图像对比度增强。因此，所提出的Dox-Fu@AuNPs可能是一种用于治疗和诊断眼部肿瘤的潜在纳米诊疗材料。
