Zhang Hongwei, Zheng Xiaoyu, Yan Zian, Guo Lijun, Zheng Yuan, Zhang Dawu, Ma Xiaochang
National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Cardiovasc Med. 2024 Dec 12;11:1439699. doi: 10.3389/fcvm.2024.1439699. eCollection 2024.
To investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.
Five different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods.
The analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, including: Total fatty acids (OR = 1.40, 95% CI: 1.28-1.53, < 0.001), Saturated fatty acids (OR = 1.44, 95% CI: 1.30-1.60, < 0.001), Serum total triglyceride levels (OR = 1.33, 95% CI: 1.22-1.46, < 0.001), Conjugated linoleic acid (OR = 1.16, 95% CI: 1.04-1.30, = 0.007). Conversely, certain metabolites were found to reduce the occurrence of coronary atherosclerosis, such as: Cholesteryl esters to total lipids ratio in medium HDL (OR = 0.73, 95% CI: 0.67-0.78, < 0.001), Cholesteryl esters to total lipids ratio in large HDL (OR = 0.64, 95% CI: 0.58-0.71, < 0.001), Total cholesterol to total lipids ratio in medium HDL (OR = 0.71, 95% CI: 0.65-0.77, < 0.001).
There is a close relationship between metabolites and the occurrence of coronary atherosclerosis. This study conducted Mendelian randomization analysis on the causal relationship between 233 metabolites and coronary atherosclerosis, providing potential new insights for the treatment of this disease.
通过孟德尔随机化分析研究233种新报道的代谢物与冠状动脉粥样硬化之间的因果关系。
采用五种不同方法对233种代谢物与冠状动脉粥样硬化进行孟德尔随机化分析，以逆方差加权法作为主要结果，并辅以其他方法。
分析确定某些代谢物会增加冠状动脉粥样硬化的易感性风险，包括：总脂肪酸（OR = 1.40，95%可信区间：1.28 - 1.53，P < 0.001）、饱和脂肪酸（OR = 1.44，95%可信区间：1.30 - 1.60，P < 0.001）、血清总甘油三酯水平（OR = 1.33，95%可信区间：1.22 - 1.46，P < 0.001）、共轭亚油酸（OR = 1.16，95%可信区间：1.04 - 1.30，P = 0.007）。相反，发现某些代谢物可降低冠状动脉粥样硬化的发生，如：中密度脂蛋白中胆固醇酯与总脂质比值（OR = 0.73，95%可信区间：0.67 - 0.78，P < 0.001）、高密度脂蛋白中胆固醇酯与总脂质比值（OR = 0.64，95%可信区间：0.58 - 0.71，P < 0.001）、中密度脂蛋白中总胆固醇与总脂质比值（OR = 0.71，95%可信区间：0.65 - 0.77，P < 0.001）。
代谢物与冠状动脉粥样硬化的发生密切相关。本研究对233种代谢物与冠状动脉粥样硬化之间的因果关系进行了孟德尔随机化分析，为该疾病的治疗提供了潜在的新见解。
